Gene therapy for pulmonary diseases
Gene therapy for pulmonary diseases
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DOI：
10.1378/chest.130.3.879
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发表时间：
2006-09-01
期刊：
影响因子：
9.6
通讯作者：
Gauldie, Jack
中科院分区：
文献类型：
--
作者：
Kolb, Martin;Martin, Gail;Gauldie, Jack
基因疗法尚未达到“早期”的高期望值。然而，它是一种很有前途的肺部疾病的新疗法。不仅像CF这样的单基因疾病是基因治疗的潜在候选者，癌症和以损伤和保护机制失衡为特征的慢性肺部疾病也是如此。本文综述了近年来更有效的基因转移系统的研究进展，并重点介绍了基因治疗的临床应用领域。
Gene therapy has not yet met the high expectations of "the early days." However, it is a promising new treatment for lung diseases. Not only single gene disorders such as CF are potential candidates for gene therapy, hut also cancer and chronic lung diseases characterized by an imbalance of damaging and protective mechanisms. This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy.