Molecular imaging of tumor blood vessels in prostate cancer.
Molecular imaging of tumor blood vessels in prostate cancer.
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发表时间：
2009-05
影响因子：
2
通讯作者：
D. Tilki;M. Seitz;B. Singer;S. Irmak;C. Stief;O. Reich;S. Ergün
中科院分区：
文献类型：
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作者：
D. Tilki;M. Seitz;B. Singer;S. Irmak;C. Stief;O. Reich;S. Ergün
在过去的三十年里，人们对肿瘤血管生成的机制进行了大量的研究。近年来，抗血管生成药物在肿瘤治疗中的应用使得肿瘤血管重建的分子成像技术的建立成为必要。通常使用的肿瘤大小的确定是不合适的，因为在抗血管生成治疗下的广泛坏死不一定导致肿瘤直径的减小。肿瘤血管的分子成像的基础是在抗血管生成治疗下肿瘤血管的重塑，这显然发生在早期阶段，并且似乎是一个令人信服的参数。在过去的几年里，除了在这一领域取得的巨大进展之外，分辨率仍然不够高，无法评价微肿瘤血管的重塑。新的成像方法相结合的特定分子标记物的肿瘤血管与不同的成像技术，需要克服这个问题的前列腺癌在这篇评论中的例子讨论。靶向血管的分子造影剂将使临床医生能够可视化在抗血管生成治疗下发生的血管重塑过程，并改善肿瘤诊断和随访。
In the past three decades many efforts have been undertaken to understand the mechanisms of tumor angiogenesis. The introduction of anti-angiogenic drugs in tumor therapy during the last few years necessitates the establishment of new techniques enabling molecular imaging of tumor vascular remodelling. The determination of tumor size as commonly used is not appropriate since the extended necrosis under anti-angiogenic therapy does not necessarily result in the reduction of tumor diameter. The basis for the molecular imaging of tumor blood vessels is the remodelling of the tumor vessels under anti-angiogenic therapy which obviously occurs at an early stage and seems to be a convincing parameter. Beside the enormous progress in this field during the last few years the resolution is still not high enough to evaluate the remodelling of the micro tumor vessels. New imaging approaches combining specific molecular markers for tumor vessels with the different imaging techniques are needed to overcome this issue as exemplarily discussed for prostate cancer in this review. Molecular contrast agents targeting the vasculature will allow clinicians the visualization of vascular remodelling processes taking place under anti-angiogenic therapy and improve tumor diagnosis and follow-up.