Comparative study of cochlear damage with three perimodiolar electrode designs
Comparative study of cochlear damage with three perimodiolar electrode designs
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DOI：
10.1097/00005537-200303000-00005
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发表时间：
2003-03-01
期刊：
影响因子：
2.6
通讯作者：
Balkany, TJ
中科院分区：
文献类型：
--
作者：
Eshraghi, AA;Yang, NW;Balkany, TJ
Objective.描述三种蜗轴周围人工耳蜗植入电极引起的耳蜗内插入损伤。研究设计：对15具人类尸体颞骨进行描述性组织学研究。方法.对15具尸体颞骨进行表面准备，并植入以下其中一种蜗轴周围电极阵列：Combi 40+PM（MedEl Corporation）、HiFocus 11（Advanced Bionics Corporation）或Contour（Covenar Corporation）。冷冻切片技术被用来研究水平部分在200妈妈的间隔与电极到位。图像增强的视频透视和计算机辅助形态测量被用来评估插入创伤的机制，并确定电极在蜗轴内的位置。结果：组织学检查显示螺旋韧带、基底膜、骨螺旋板均有不同程度的损伤。使用一种新的电极创伤分级系统，三种电极之间没有统计学显著差异。对常用“标准”电极的组织学研究进行的文献检索显示，损伤等于或大于当前研究中观察到的损伤。结论：乳头周围电极引起的插入创伤发生在可接受的程度。基于创伤机制的电极改进可能能够进一步减少损伤。
Objective. To describe intracochlear insertion trauma caused by three perimodiolar cochlear implant electrodes. Study Design: Descriptive histological study of 15 human cadaver temporal bones. Methods. Fifteen cadaver temporal bones underwent surface preparation and were implanted with one of the following perimodiolar electrode arrays: Combi 40+PM (MedEl Corporation), HiFocus 11 (Advanced Bionics Corporation), or Contour (Cochlear Corporation). A cryosectioning technique was used to study horizontal sections at 200-mum intervals with the electrode in place. Image-enhanced videofluoroscopy and computer-assisted morphometrics were used to assess the mechanism of insertion trauma and to determine electrode position within the modiolus. Results: Histological examination revealed varying degrees of damage to the spiral ligament, basilar membrane, and osseous spiral lamina. Using a novel grading system for electrode trauma, there was no statistically significant difference among the three electrodes. A literature search of histological studies of a commonly used "standard" electrode showed damage equal to or greater than that seen in the current study. Conclusions: Insertion trauma caused by periomodiolar electrodes occurs to an acceptable degree. Refinement of electrodes based on mechanisms of trauma may be able to further reduce damage.