Emerging features of ER resident J-proteins in plants
Emerging features of ER resident J-proteins in plants
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DOI：
10.4161/psb.28194
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发表时间：
2014-03
影响因子：
2.9
通讯作者：
Masaru Ohta;F. Takaiwa
中科院分区：
文献类型：
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作者：
Masaru Ohta;F. Takaiwa
J蛋白是HSP 70系统的共分子伴侣。J蛋白刺激Hsp 70 ATP酶活性，其负责稳定Hsp 70与客户蛋白的相互作用。J蛋白定位于各种细胞内区室，包括细胞质、线粒体和内质网（ER）。在植物中发现了5种ER常驻J蛋白（ERdjs）（P58、ERdj 2、ERdj 2A、ERdj 3B和ERdj 7）。水稻OsERdj 3A在内质网胁迫下定位于液泡和蛋白质储存液泡（PSV、PB-II）中。定位于液泡或溶酶体的J蛋白在哺乳动物和酵母中未发现，这表明OsERdj 3A在液泡中的存在是植物特异性的，并且是植物ERdjs所特有的特征之一。本文综述了植物ERdjs的研究现状和最新研究进展，并对哺乳动物和酵母ERdjs与植物ERdjs进行了比较。
J-proteins are co-chaperone components of the HSP70 system. J-proteins stimulate Hsp70ATPase activity, which is responsible for stabilizing the interaction of Hsp70 with client proteins. J-proteins are localized in various intracellular compartments including the cytoplasm, mitochondria and endoplasmic reticulum (ER). Five types of ER resident J-proteins (ERdjs) have been found in plants (P58, ERdj2, ERdj2A, ERdj3B and ERdj7). Rice OsERdj3A is located in the vacuole and protein storage vacuoles (PSV, PB-II) under conditions of ER stress. J-proteins that are localized to the vacuole or lysosome are not found in mammals and yeast, suggesting that the presence of OsERdj3A in the vacuole is plant-specific and one of the features unique to plant ERdjs. In this review, we summarize the current state of knowledge and recent research advancements regarding plant ERdjs, and compare mammalian and yeast ERdjs with plant ERdjs.