Distinctive flow pattern of wall shear stress and oscillatory shear index: similarity and dissimilarity in ruptured and unruptured cerebral aneurysm blebs
Distinctive flow pattern of wall shear stress and oscillatory shear index: similarity and dissimilarity in ruptured and unruptured cerebral aneurysm blebs
复制标题
壁剪应力和振荡剪切指数的独特流动模式：破裂和未破裂脑动脉瘤栓子的相似性和差异性
DOI：
10.3171/2012.7.jns111991
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发表时间：
2012-10-01
影响因子：
4.1
通讯作者：
Nishijima, Michiharu
中科院分区：
文献类型：
--
作者：
Kawaguchi, Tomohiro;Nishimura, Shinjitsu;Nishijima, Michiharu
Object.破裂和未破裂动脉瘤之间的壁面剪切应力（WSS）和振荡剪切指数（OSI）的血流动力学差异尚不清楚。作者研究了破裂和薄壁未破裂动脉瘤泡的血流动力学相似性和差异性。采用基于磁共振成像的流体动力学分析计算WSS和OSI，并比较血流动力学和术中结果。作者还比较了破裂和未破裂的薄壁水泡的WSS和OSI的大小。结果。术中，确定了13个破裂和139个薄壁未破裂动脉瘤泡。破裂组12例（92.3%），未破裂组124例（89.2%），WSS低，OSI高。破裂滤过泡的WSS程度（0.49 ± 0.12 Pa）显著低于未破裂滤过泡（0.64 ± 0.15 Pa; p < 0.01）。破裂和未破裂的水泡共享一个独特的模式，低WSS和高OSI。破裂部位的WSS程度明显低于未破裂的薄壁滤过泡。(http：//thejns.org/doi/abs/10.3171/2012.7.JNS111991）
Object. The difference in the hemodynamics of wall shear stress (WSS) and oscillatory shear index (OSI) between ruptured and unruptured aneurysms is not well understood. The authors investigated the hemodynamic similarities and dissimilarities in ruptured and thin-walled unruptured aneurysm blebs.Methods. Magnetic resonance imaging based fluid dynamics analysis was used to calculate WSS and OSI, and hemodynamic and intraoperative findings were compared. The authors also compared ruptured and unruptured thin-walled blebs for the magnitude of WSS and OSI.Results. Intraoperatively, 13 ruptured and 139 thin-walled unruptured aneurysm blebs were identified. Twelve of the ruptured (92.3%) and 124 of the unruptured blebs (89.2%) manifested low WSS and high OSI. The degree of WSS was significantly lower in ruptured (0.49 +/- 0.12 Pa) than in unruptured (0.64 +/- 0.15 Pa; p < 0.01) blebs.Conclusions. Ruptured and unruptured blebs shared a distinctive pattern of low WSS and high OSI. The degree of WSS at the rupture site was significantly lower than in the unruptured thin-walled blebs. (http://thejns.org/doi/abs/10.3171/2012.7.JNS111991)