Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models
Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models
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DOI：
10.26717/bjstr.2019.14.002617
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发表时间：
2019-02
期刊：
影响因子：
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通讯作者：
Longhui Qiu;Z. Zhang
中科院分区：
文献类型：
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作者：
Longhui Qiu;Z. Zhang
缺血/再灌注损伤（IRI）是所有移植器官所固有的，并且与早期肾移植功能和移植物寿命不利相关。尽管免疫抑制方案和围手术期护理取得了进展，但迄今为止还没有 FDA 批准的肾移植 IRI 治疗方法。近年来，通过利用改良的临床相关的肾移植（KTx）小鼠模型（其中延长的热或冷缺血时间诱导延长的IRI），研究已经确定了KTx IRI的几种潜在治疗方法，包括激素补充、促进肾小管修复和再生、靶向补体系统、炎症和坏死性凋亡。这篇综述描述了从 KTx 小鼠模型中学到的一些关于影响移植 IRI 严重程度的因素和潜在治疗靶点的经验教训。
Ischemia/reperfusion injury (IRI) is inherent to all transplanted organs and is adversely associated with early renal graft function and graft longevity. Despite the progress in immunosuppressive regimens and perioperative care, no FDA-approved treatment for kidney transplant IRI is available to date. In recent years, by utilizing the modified and clinically-relevant mouse models of kidney transplantation (KTx) in which extended IRI is induced by the prolonged warm or cold ischemic time, studies have identified several potential therapeutic approaches for KTx IRI, including the hormone supplement, promoting tubular repair and regeneration, and targeting complement system, inflammation, and necroptosis. This review describes some of the lessons learned from mouse models of KTx with regard to factors that influence the severity of transplant IRI and the potential therapeutic targets.