AN M3-LIKE MUSCARINIC AUTORECEPTOR REGULATES THE INVIVO RELEASE OF ACETYLCHOLINE IN RAT STRIATUM
AN M3-LIKE MUSCARINIC AUTORECEPTOR REGULATES THE INVIVO RELEASE OF ACETYLCHOLINE IN RAT STRIATUM
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DOI：
10.1016/0014-2999(90)90414-2
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发表时间：
1990-04-10
影响因子：
5
通讯作者：
HORN, AS
中科院分区：
文献类型：
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作者：
DEBOER, P;WESTERINK, BHC;HORN, AS
选择性M受体拮抗剂被用来描述大鼠纹状体中调节乙酰胆碱释放的M受体。在体微透析应用阿托品、4-DAMP(4-二苯基乙酰氧基-N-甲基哌啶)、哌仑西平或AF-DX 116(11-[[2-[(二乙氨基)甲基]-1-哌啶基]乙酰基]-5，11-二氢[2，3-b][1，4]苯二氮卓-6-酮)，导致乙酰胆碱的溢出量呈剂量依赖性增加，效力顺序为：阿托品和GT；4-DAMP和GT；哌仑西平和GT；AF-DX 116。根据这些数据，我们得出结论，纹状体中调节M受体释放的是M3型。
Selective muscarinic antagonists were used in an attempt to characterize the muscarinic autoreceptor modulating the release of acetylcholine in the striatum of the rat. In vivo microdialysis was applied to infuse atropine, 4-DAMP (4-diphenylacetoxy-N-methylpiperidine), pirenzepine or AF-DX 116 (11-[[2-[(diethylamino)methyl]-1- piperidinyl]acetyl]-5, 11-dihydro[2,3-b][1,4]benzodiazepine-6-one), leading to a dose-dependent increase in the overflow of acetylcholine, the order of potency being: atropine > 4-DAMP > pirenzepine > AF-DX 116. We conclude from these data that the muscarinic receptor modulating release in the striatum is of the M3type.