Bio-synthesis of food additives and colorants-a growing trend in future food.
Bio-synthesis of food additives and colorants-a growing trend in future food.
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DOI：
10.1016/j.biotechadv.2020.107694
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发表时间：
2020-12
影响因子：
16
通讯作者：
Lichao Sun;F. Xin;H. Alper
中科院分区：
文献类型：
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作者：
Lichao Sun;F. Xin;H. Alper
食品添加剂和着色剂广泛用于食品工业，以提高食品加工、储存和包装过程中的质量和安全性。这些分子的来源主要通过三种方式：从天然来源提取，化学合成和生物生产，前两种是最常用的。然而，对可持续性、安全性和“天然”产品的需求日益增长，重新引起了人们对使用生物基生产方法的兴趣。同样，转向更多的养殖食品和肉类替代品需要生产新的添加剂和着色剂。生物基食品添加剂和着色剂的生产是一项跨学科的研究奋进，代表了未来食品的发展趋势。为了突出微生物宿主在食品添加剂和着色剂生产中的潜力，我们重点介绍了目前的进展，例如基于其利用阶段和生物生产产量的分子，如下：（I）批准和工业化生产的高滴度;（II）批准和生产的体面滴度（g/L范围内），但需要进一步的工程设计以降低生产成本;（III）以非常早期的滴度获得批准和生产（在mg/L范围内）;和（IV）尚未批准但可以通过微生物来源的新的/潜在的候选物。有前途的方法，以及目前的挑战和未来的方向也将彻底讨论这些食品添加剂和着色剂的生物生产。
Food additives and colorants are extensively used in the food industry to improve food quality and safety during processing, storage and packing. Sourcing of these molecules is predominately through three means: extraction from natural sources, chemical synthesis, and bio-production, with the first two being the most utilized. However, growing demands for sustainability, safety and “natural” products have renewed interest in using bio-based production methods. Likewise, the move to more cultured foods and meat alternatives requires the production of new additives and colorants. The production of bio-based food additives and colorants is an interdisciplinary research endeavor and represents a growing trend in future food. To highlight the potential of microbial hosts for food additive and colorant production, we focus on current advances for example molecules based on their utilization stage and bio-production yield as follows: (I) approved and industrially produced with high titers; (II) approved and produced with decent titers (in the g/L range), but requiring further engineering to reduce production costs; (III) approved and produced with very early stage titers (in the mg/L range); and (IV) new/potential candidates that have not been approved but can be sourced through microbes. Promising approaches, as well as current challenges and future directions will also be thoroughly discussed for the bioproduction of these food additives and colorants.