Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome
Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome
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DOI：
10.1016/j.orthres.2004.05.014
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发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Lotz, JC
中科院分区：
文献类型：
--
作者：
Diao, E;Shao, F;Lotz, JC
背景资料：提出了一种腕管综合征（CTS）的体内动物模型，其允许对腕管内的正中神经分级施加压力。我们假设这种压力会以剂量相关的方式引起正中神经的电生理变化，NCS/EMG变化与人类CTS一致。在40只新西兰白色家兔中，体重2 - 2.5 kg，将血管成形术导管放置在前爪的腕管中，并将50至80 mm Hg的压力施加到一侧，而对侧用作腕管。控制和保持不膨胀。结果：所有实验肢体的远端运动潜伏期均增加15%，其中15侧肢体的远端运动潜伏期延长15%，其余肢体的远端运动潜伏期延长15%。对照组肢体远端运动潜伏期均无显著增加。在实验动物中，15%的延迟是在大约4-5周的50-70毫米汞柱组和在大约1周的80毫米汞柱group.Conclusion：这种新的动物模型CTS表现出直接的因果关系腕管压力和正中神经功能障碍之间的关系。我们预计，这种具有临床相关结果的体内模型将有助于识别损伤机制，并将作为未来开发新型干预和治疗方法的基础。(C)2004骨科研究学会。由爱思唯尔有限公司出版。保留所有权利。
Background: An in vivo animal model for carpal tunnel syndrome (CTS) is presented which allows for graded application of pressure to the median nerve within the carpal canal. We hypothesized that Such pressure would cause electrophysiologic changes ill the median nerve in a dose-related manner, with NCS/EMG changes consistent with CTS in humans.Methods: In 40 New Zealand white rabbits, ranging from 2 to 2.5 kg, angioplasty catheters were placed in the carpal tunnel in the forepaws and pressures ranging from 50 to 80 mm Hg applied to one side while the contralateral side served as the control and remained uninflated. Pressure was applied until a 15% increase in distal motor latency was obtained for 2 consecutive weeks by nerve conduction studies.Results: All the experimental limbs exhibited a 15% increase in distal motor latency. None of the control limbs showed a Significant increase in distal motor latency. In the experimental animals the 15% delay was achieved in approximately 4-5 weeks in the 50-70 mm Hg groups and in approximately 1 week in the 80 mm Hg group.Conclusion: This new animal model for CTS demonstrates a direct cause and effect relationship between carpal tunnel pressure and median nerve dysfunction. We anticipate that this in vivo model with clinically relevant outcomes will facilitate identification of injury mechanisms, and will serve as a basis for future development of novel interventions and treatments. (C) 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.