A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate
A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate
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DOI：
10.1093/jn/137.1.135
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
Hambidge, K. Michael
中科院分区：
文献类型：
--
作者：
Miller, Leland V.;Krebs, Nancy F.;Hambidge, K. Michael
膳食中锌和植酸的含量是决定锌吸收的主要因素。作为膳食锌和植酸盐的函数的锌吸收的数学模型可用于预测膳食锌需要量，并且潜在地增强我们对锌吸收的理解。我们的目标是开发一个模型的实用性和信息价值的基础上的锌吸收过程的基本知识，然后适合模型选择的已发表的数据，以评估其有效性和估计参数值。一个中等数学复杂性的模型，总锌的吸收，总膳食锌和总膳食植酸的推导和拟合21个平均数据，从全天吸收的研究，采用非线性回归分析。使用标准统计标准评价模型有效性、拟合优度、回归假设的满意度和参数估计值的质量。拟合的R-2为0.82。发现残差呈现正态分布、恒定方差和独立性。模型参数A（MAX）、K-R和K-p分别为0.13、0.10和1.2 mmol/d。其中几个估计值的置信区间较宽，部分原因是数据数量少且分散。该模型被认为是有效的，对研究和预测吸收具有直接价值。现有数据不支持采用被动吸收机制的模型。J.营养137：135-141，2007.
The quantities of zinc and phytate in the diet are the primary factors determining zinc absorption. A mathematical model of zinc absorption as a function of dietary zinc and phytate can be used to predict dietary zinc requirements and, potentially, enhance our understanding of zinc absorption. Our goal was to develop a model of practical and informative value based on fundamental knowledge of the zinc absorption process and then fit the model to selected published data to assess its validity and estimate parameter values. A model of moderate mathematical complexity relating total zinc absorption to total dietary zinc and total dietary phytate was derived and fit to 21 mean data from whole day absorption studies using nonlinear regression analysis. Model validity, goodness of fit, satisfaction of regression assumptions, and quality of the parameter estimates were evaluated using standard statistical criteria. The fit had an R-2 of 0.82. The residuals were found to exhibit a normal distribution, constant variance, and independence. The parameters of the model, A(MAX), K-R, and K-p, were estimated to have values of 0.13,0.10, and 1,2 mmol/d, respectively. Several of these estimates had wide Cl attributable in part to the small number and the scatter of the data. The model was judged to be valid and of immediate value for studying and predicting absorption. A version of the model incorporating a passive absorption mechanism was not supported by the available data. J. Nutr. 137: 135-141, 2007.