BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
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DOI：
10.1016/j.canlet.2011.01.019
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发表时间：
2011-04-01
期刊：
影响因子：
9.7
通讯作者：
Saito, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Suzuki, Miwa;Iwasaki, Masahiro;Saito, Tsuyoshi
BAG 3（BCL 2-associated athanogene 3）是BAG家族蛋白的成员，其与Hsp 70相互作用并调节Hsp 70。本研究的目的是将BAG 3在卵巢癌中的表达与侵袭性和无进展生存期相关联。我们发现，在培养的卵巢癌细胞中，BAG 3与MMP 2相互作用，并且BAG 3表达的敲低下调MMP 2的表达，并降低细胞的运动性和侵袭性。BAG 3阳性的发生率在晚期卵巢癌的临床阶段明显高于早期阶段。我们认为，BAG 3结合MMP 2，积极调节细胞侵袭的过程。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
BAG3 (BCL2-associated athanogene 3) is a member of the BAG family proteins, which interact with and regulate Hsp70. Our aim in the present study was to correlate BAG3 expression in ovarian cancer with invasion and progression-free survival. We found that BAG3 interacts with MMP2 in cultured ovarian cancer cells, and that knockdown of BAG3 expression downregulated MMP2 expression and diminished cell motility and invasiveness. The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. We suggest that BAG3 binds to MMP2 to positively regulate the process of cell invasion. (C) 2011 Elsevier Ireland Ltd. All rights reserved.