Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria
Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria
复制标题
岩藻聚糖可抑制高脂饮食引起的肥胖并丰富降解岩藻依聚糖的肠道细菌
DOI：
10.1016/j.carbpol.2022.119411
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发表时间：
2022-04-27
影响因子：
11.2
通讯作者：
Wang, Hong
中科院分区：
文献类型：
--
作者：
Wei, Bin;Zhang, Bo;Wang, Hong
低分子量海藻多糖作为预防肥胖和肠道微生物群失调的新型治疗剂显示出有希望的潜力。多糖和肠道微生物群之间的相互作用可能在其抗肥胖作用中发挥关键作用，但在很大程度上是未知的，包括多糖对具有多糖降解能力的肠道微生物群组成的影响。对来自日本竹荪的5.1 kDa岩藻聚糖（J2 H）的一级结构进行了表征，口服J2 H可有效抑制高脂饮食诱导的肥胖、血糖代谢障碍、血脂异常和肠道微生物群失调。此外，Jensen-Shannon分歧分析表明，J2 H富集了至少四种具有岩藻聚糖降解潜力的肠道细菌物种，包括赛氏拟杆菌和产酸拟杆菌。我们的研究结果表明，低分子量S。日本岩藻聚糖（J2 H）是一种很有前途的预防肥胖的潜在药物，其富集具有岩藻聚糖降解潜力的肠道细菌可能在抗肥胖作用中起重要作用。
Low molecular weight seaweed polysaccharides exhibit promising potential as novel therapeutics for the prevention of obesity and gut microbiota dysbiosis. The interplay between polysaccharides and gut microbiota may play crucial roles in their anti-obesity effects, but is largely unknown, including the impact of polysaccharides on the composition of the gut microbiota with polysaccharide-degrading capacity. The primary structure of a 5.1 kDa fucan (J2H) from Saccharina japonica was characterized and oral administration of J2H effectively suppressed high-fat diet-induced obesity, blood glucose metabolic dysfunction, dyslipidemia, and gut microbiota dysbiosis. Furthermore, the Jensen-Shannon divergence analysis demonstrated that J2H enriched at least four gut bacterial species with fucoidan-degrading potential, including Bacteroides sartorii and Bacteroides acidifaciens. Our findings suggest that the low molecular weight S. japonica fucan, J2H, is a promising potential agent for obesity prevention and its enrichment of gut bacteria with fucoidan-degrading potential may play a vital role in the anti-obesity effects.