LOCOMOTOR-ACTIVITY IN RELATION TO DOPAMINE AND NORADRENALINE IN THE NUCLEUS-ACCUMBENS, SEPTAL AND FRONTAL AREAS - A 6-HYDROXYDOPAMINE STUDY
LOCOMOTOR-ACTIVITY IN RELATION TO DOPAMINE AND NORADRENALINE IN THE NUCLEUS-ACCUMBENS, SEPTAL AND FRONTAL AREAS - A 6-HYDROXYDOPAMINE STUDY
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DOI：
10.1159/000118294
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发表时间：
1986-01-01
影响因子：
3.2
通讯作者：
LEMOAL, M
中科院分区：
文献类型：
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作者：
OADES, RD;TAGHZOUTI, K;LEMOAL, M
6-羟多巴胺处理大鼠腹侧被盖区（VTA）、中隔和额叶皮层的圆形走廊自动记录运动活动。对照组和实验组在新装置中表现出相似的高运动反应，持续3小时。与其他病变和对照组相比，VTA病变导致暗区活动增加，对阿波啡的反应很大。中隔病变不影响运动。阿波啡治疗后，额叶组运动能力略有增加，这可能反映了皮层或皮层下区域受体敏感性的增加。结合运动活动与皮层多巴胺和去甲肾上腺素水平之间的相关性，这些结果被解释为支持多巴胺、去甲肾上腺素和额叶皮层在调节运动中的作用，而运动主要是由伏隔区多巴胺活动介导的。
Locomotor activity was automatically recorded in a circular corridor in rats treated with 6-hydroxydopamine in the ventral tegmental area (VTA), septum and frontal cortex. Control and experimental groups showed similar hyperlocomotor responses in the novel apparatus lasting 3 h. Circadian changes are described. VTA lesions resulted in increased dark activity and a large response to apomorphine compared to other lesion and control groups. Septal lesions did not affect locomotion. The frontal group showed a small increase of locomotion after apomorphine treatment that might reflect increased recetor sensitivity in cortical or subcortical areas. Together with correlations between motor activity and cortical levels of dopamine and noradrenaline these results are interpreted to support a role for dopamine, noradrenaline and the frontal cortex in modulating locomotion which is primarily mediated by VTA-accumbens-dopamine activity.