EFFECTS OF PSYCHOSOCIAL STRESSORS ON MOUSE MAMMARY TUMOR GROWTH
EFFECTS OF PSYCHOSOCIAL STRESSORS ON MOUSE MAMMARY TUMOR GROWTH
复制标题
DOI：
10.1016/0889-1591(89)90039-1
复制
发表时间：
1989-01-01
影响因子：
15.1
通讯作者：
EMERMAN J T
中科院分区：
文献类型：
--
作者：
WEINBERG J;EMERMAN J T
我们描述了一个敏感和可复制的动物模型，表明心理社会变量都增加和减少肿瘤生长速度。研究了社会住房条件和每日暴露于新环境对可移植雄激素反应性Shionogi小鼠乳腺癌（SC 115）小鼠的影响。如果动物也暴露于急性每日新奇应激，则单独饲养和保持单独饲养或在同胞组中饲养然后在肿瘤细胞注射后单独饲养的小鼠与保持在其标准同胞饲养组中的小鼠（每组n = 2-3）相比显著增加肿瘤生长。相比之下，被单独饲养，然后转移到一个更大的社会群体（每组n = 4-5个非兄弟姐妹）显着减少肿瘤生长，无论是急性日常新奇压力的存在与否。
We describe a sensitive and replicable animal model which demonstrates that psychosocial variables both increase and decrease tumor growth rate. The effects of social housing condition and daily exposure to novel environments were investigated in mice bearing the transplantable androgen-responsive Shionogi mouse mammary carcinoma (SC115). Being reared individually housed and remaining individually housed or being reared in a sibling group and then singly housed following tumor cell injection markedly increased tumor growth compard to that in mice remaining in their standard sibling rearing groups (n = 2-3 per group), if animals were also exposed to acute daily novelty stress. In contrast, being reared individually and then moved to a larger social group (n = 4-5 nonsiblings per group) markedly reduced tumor growth, both the presence and absence of acute daily novelty stress.