Endothelial Cell Heterogeneity
Endothelial Cell Heterogeneity
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DOI：
10.1101/cshperspect.a006429
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发表时间：
2012-01-01
影响因子：
5.4
通讯作者：
Aird, William C.
中科院分区：
文献类型：
--
作者：
Aird, William C.
血管的内皮衬里在结构和功能、时间和空间、健康和疾病方面显示出显著的异质性。了解表型异质性的分子基础可能为血管床特异性治疗提供重要的见解。首先，我们回顾了内皮异质性的范围，并讨论了其近似和进化机制。其次，我们将这些原则及其治疗意义应用于疾病中的代表性血管床，即肿瘤内皮。
The endothelial lining of blood vessels shows remarkable heterogeneity in structure and function, in time and space, and in health and disease. An understanding of the molecular basis for phenotypic heterogeneity may provide important insights into vascular bed-specific therapies. First, we review the scope of endothelial heterogeneity and discuss its proximate and evolutionary mechanisms. Second, we apply these principles, together with their therapeutic implications, to a representative vascular bed in disease, namely, tumor endothelium.