Sonic hedgehog signaling is essential for hair development
Sonic hedgehog signaling is essential for hair development
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DOI：
10.1016/s0960-9822(98)70443-9
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发表时间：
1998-09-24
期刊：
影响因子：
9.2
通讯作者：
McMahon, AP
中科院分区：
文献类型：
--
作者：
St-Jacques, B;Dassule, HR;McMahon, AP
背景资料：皮肤负责形成脊椎动物之间不同的各种表皮结构，由于上皮-间充质与下层真皮间充质的相互作用，由表皮基板产生，Wnt、Hedgehog和骨形态发生蛋白家族成员的表达此外，它们的表达继续进入形成毛发本身的表皮来源的毛发基质，或负责诱导毛发基质的真皮乳头。为了解决的作用Shh在毛囊中，我们已经检查了Shh null突变mice.Results：我们发现，毛囊发育在Shh突变胚胎逮捕后，最初的表皮-真皮的相互作用，导致形成的毛乳头原基和向内生长的表皮，Wnt 10 b，Bmp 2和Bmp 4继续在这个时候表达，但是。当移植到裸鼠（缺乏T细胞），Shh突变皮肤引起了大的异常毛囊含有一个小的毛乳头，虽然这些毛囊表现出高增殖率和一些分化的毛基质细胞成毛干样materials.Conclusions：Shh信号是不需要启动毛囊发育。然而，Shh信号对于控制毛囊的向内生长和形态发生至关重要。
Background: The skin is responsible for forming a variety of epidermal structures that differ amongst vertebrates, In each case the specific structure (for example scale, feather or hair) arises from an epidermal placode as a result of epithelial-mesenchymal interactions with the underlying dermal mesenchyme, Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4 respectively) in the epidermis correlates with the initiation of hair follicle formation, Further, their expression continues into either the epidermally derived hair matrix which forms the hair itself, or the dermal papilla which is responsible for induction of the hair matrix. To address the role of Shh in the hair follicle, we have examined Shh null mutant mice.Results: We found that follicle development in the Shh mutant embryo arrested after the initial epidermal-dermal interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis, Wnt10b, Bmp2 and Bmp4 continued to be expressed at this time, however. When grafted to nude mice (which lack T cells), Shh mutant skin gave rise to large abnormal follicles containing a small dermal papilla, Although these follicles showed high rates of proliferation and some differentiation of hair matrix cells into hair-shaft-like material, no hair was formed.Conclusions: Shh signaling is not required for initialing hair follicle development. Shh signaling is essential, however, for controlling ingrowth and morphogenesis of the hair follicle.