Biodegradable polymer scaffolds with well-defined interconnected spherical pore network
Biodegradable polymer scaffolds with well-defined interconnected spherical pore network
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DOI：
10.1089/107632701300003269
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发表时间：
2001-02-01
影响因子：
--
通讯作者：
Choi, JW
中科院分区：
文献类型：
--
作者：
Ma, PX;Choi, JW
支架在组织工程中起着举足轻重的作用。在这项工作中，开发了一种新的加工技术，以创建具有良好控制的相互连接的球形孔的三维可生物降解聚合物支架。采用分散法制备了石蜡微球，通过热处理将石蜡微球粘结在一起，在模具中形成三维组装。将PLLA和PLGA等可生物降解聚合物溶解在溶剂中，浇铸到石蜡球体组装件上。溶解石蜡后，形成了多孔的聚合物支架。研究了制备参数对聚合物支架的孔形状、孔间连通性、孔壁形态和力学性能的影响。支架的压缩弹性系数随孔隙率的增加而减小。石蜡微球的热处理时间越长，支架之间的孔洞越大。较小孔径(100-200微米)的泡沫材料的压缩弹性系数显著低于较大孔径(250-350微米或420-500微米)的泡沫。PLLA泡沫塑料具有由小血小板组成的骨架结构，而PLGA泡沫塑料具有均匀的骨架结构。这种新的加工技术可以为各种潜在的组织工程应用量身定做聚合物支架，因为它的结构、孔间连通性和力学性能都得到了很好的控制。
Scaffolding plays pivotal role in tissue engineering. In this work, a novel processing technique has been developed to create three-dimensional biodegradable polymer scaffolds with well-controlled interconnected spherical pores. Paraffin spheres were fabricated with a dispersion method, and were bonded together through a heat treatment to form a three-dimensional assembly in a mold. Biodegradable polymers such as PLLA and PLGA were dissolved in a solvent and cast onto the paraffin sphere assembly. After dissolving the paraffin, a porous polymer scaffold was formed. The fabrication parameters were studied in relation to the pore shape, interpore connectivity, pore wall morphology, and mechanical properties of the polymer scaffolds. The compressive modulus of the scaffolds decreased with increasing porosity. Longer heat treatment time of the paraffin spheres resulted in larger openings between the pores of the scaffolds. Foams of smaller pore size (100-200 mum) resulted in significantly lower compressive modulus than that of larger pore sizes (250-350 or 420-500 mum). The PLLA foams had a skeletal structure consisting of small platelets, whereas PLGA foams had homogeneous skeletal structure. The new processing technique can tailor the polymer scaffolds for a variety of potential tissue engineering applications because of the well-controlled architecture, interpore connectivity, and mechanical properties.