Erythrocyte water permeability. The effects of anesthetic alcohols and alterations in the level of membrane cholesterol.
Erythrocyte water permeability. The effects of anesthetic alcohols and alterations in the level of membrane cholesterol.
复制标题
红细胞水渗透性。
DOI：
10.1016/0005-2736(80)90455-1
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Forster,RE
中科院分区：
文献类型：
--
作者：
Kutchai,H;Cooper,RA;Forster,RE
1. 用麻醉正烷醇（戊醇、己醇和肝醇）治疗人红细胞可导致红细胞细胞膜的渗透性降低。2. 醇引起的渗透水渗透性变化与醇浓度成正比，并大致平行于醇引起的二苯己三烯。3. 红细胞中胆固醇的富集也会导致渗透水渗透性的降低。4. 膜胆固醇的适度消耗（9%或40%）对渗透水的渗透性没有影响，即使这种处理导致膜脂中二苯己三烯的旋转流动性显著增加。
1. Treatment of human erythrocytes with anesthetic n-alkanols (pentanol, hexanol and hepatanol) results in a decrease in the osmotic water permeability of the red cell membrane. 2. The alcohol-induced changes in osmotic water permeability are proportional to the alcohol concentration and roughly parallel diphenylhexatriene that are induced by the alcohols. 3. Enrichment of the red cell membrane in cholesterol also results in a decrease in the osmotic water permeability. 4. Moderate depletion (9% or 40%) of membrane cholesterol is without effect on the osmotic water permeability, even though this treatment results in a significant increase in the rotational mobility of diphenylhexatriene in the membrane lipids.