The Virological and Epidemiological Features of COVID-19 in Anhui, China-猫眼课题宝

DOI：

10.2139/ssrn.3551351

发表时间：

2020-03

期刊：

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Jun He;Yong Sun;Lijie Wang;Jia-bing Wu;L. Gong;S. Hou;Junling Yu;Qingqing Chen;Weiwei Li;Yuan Yuan-Yuan;Yonglin Shi;Yongjun Gao;Zhuhui Zhang;M. Zhu;Lan He;Yinglu Ge;L. Weidong;Zhirong Liu;R. Gao

背景：SARS-CoV-2自2019年12月在武汉出现以来，在中国和多个国家引发了巨大疫情，中国。病毒引起的疾病(新冠肺炎)因其传播速度快、流动性高、死亡率高而引起世界关注。方法：对安徽省914例确诊的新冠肺炎患者中国进行现场调查。实时荧光定量RT-PCR(RRT-PCR)证实患者感染SARS-CoV-2。有关人口学特征和接触史的信息从确诊病例的患者那里获得。我们对这些患者进行了病毒学和流行病学分析。结果：痰标本的RRT-PCRCT值明显低于咽拭子标本。在疾病早期或晚期，甚至在个别患者发病当天或发病后第20天，也可检测到低CT值的病毒。CT值与疾病早期严重程度的发生率及年龄分组无明显相关性。男性、高龄患者、延误诊断与新冠肺炎病情加重呈正相关，而感染发生增多与病情加重呈负相关。解读：病毒载量与新冠肺炎早期的严重程度无关。男性和延迟诊断增加了新冠肺炎严重程度增加的风险，同时随着感染世代的增加而降低了风险。SARS-CoV-2可能通过在单个人宿主内的长期复制增加人与人之间的传播性。资助说明：本研究得到国家传染病重大专项(批准号：2017ZX10304402001-019)和中国国家自然科学基金(批准号：81971946)的资助。安徽省新型冠状病毒感染应急研究项目(批准号：202004a07020002；202004a07020004)。利益申报：无。伦理批准声明：病例和密切接触者的数据收集和分析被中华人民共和国国家卫生委员会确定为持续的公共卫生暴发调查的一部分，因此被认为免于机构审查委员会的批准。

Background: SARS-CoV-2 has caused a huge outbreak in China and multiple countries since it emerged in Wuhan, China in December, 2019. The virus caused diseases (COVID-19) has raised world concern because of rapid transmissibility, high mobility and mortality. Methods: Field investigations were conducted for 914 confirmed patients with COVID-19 in Anhui province, China. Patients were confirmed to be infected with SARS-CoV-2 by real-time RT-PCR (rRT-PCR). Information on demographic characteristics, and exposure history was obtained from patients with confirmed cases. We conducted virological and epidemiological analysis on these patients. Findings: The rRT-PCR Ct values were remarkably lower in sputum samples than throat swab samples. The virus was detected with a low Ct value at early or late stage of illness, even at the day of illness onset or day 20 after illness onset in individual patients. Ct values didn’t show a significant association with incidence of severity at early stage of illness or grouped ages. Male, older patients and delayed diagnosis showed positive association with enhancing severity of COVID-19 but increased generation of infection was negative association with the enhancing severity. Interpretation: Viral load was not related to the severity of COVID-19 in early stage of COVID-19. Male and delayed diagnosis increased a risk of enhancing COVID-19 severity while decreased the risk with increasing generation of infection. SARS-CoV-2 may increase human-to-human transmissibility through long term replication within individual human host. Funding Statement: This work was supported by the National Mega-projects for Infectious Diseases (grant numbers 2017ZX10304402-001-019) and National Natural Scientific Foundation of China (grant numbers 81971946). Emergency research project of novel coronavirus infection of Anhui province (grant numbers 202004a07020002; 202004a07020004). Declaration of Interests: None. Ethics Approval Statement: Data collection and analysis of cases and close contacts were determined by the National Health Commission of the People’s Republic of China to be part of a continuing public health outbreak investigation and were thus considered exempt from institutional review board approval.

The Virological and Epidemiological Features of COVID-19 in Anhui, China

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