Drebrin in Neuronal Migration and Axonal Growth
Drebrin in Neuronal Migration and Axonal Growth
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DOI：
10.1007/978-4-431-56550-5_9
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发表时间：
2017-01-01
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影响因子：
--
通讯作者：
Hanamura, Kenji
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文献类型：
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作者：
Hanamura, Kenji
在发育过程中，从神经干细胞产生神经元，神经元从其出生地迁移到其最终位置，以及神经突、轴突和树突的延伸对于功能性神经回路的形成是重要的。肌动蛋白细胞骨架在神经元的形态发育中具有重要作用。在这一章中，我们集中在肌动蛋白结合蛋白，drebrin的分布和功能，阐明drebrin结合的F-肌动蛋白在神经元在胚胎，出生后，和成人大脑的神经元的早期发育阶段的重要性。鸡脑中有三种主要的drebrin亚型（E1、E2和A），哺乳动物脑中有两种主要亚型（E和A）。在这些dreplastin亚型中，鸡中的dreplastin E1和E2以及哺乳动物脑中的dreplastin E参与这些神经元阶段。在发育和成年脑的迁移神经元中，drepletin定位于主导过程的丝状伪足基部，以调节神经元的迁移。在轴突生长锥中，dreplastin位于过渡区，通过抑制肌动球蛋白相互作用和介导F-actin与微管之间的相互作用来调节轴突生长。在轴突侧支分支中，轴突侧支定位于轴突肌动蛋白片和丝状伪足基部，以加速肌动蛋白片向丝状伪足的过渡并稳定丝状伪足。
During development, production of neurons from neural stem cells, migration of neurons from their birthplace to their final location, and extension of neurites, axons, and dendrites are important for the formation of functional neuronal circuits. The actin cytoskeleton has major roles in the morphological development of neurons. In this chapter, we focused on the distribution and function of the actin-binding protein, drebrin, to elucidate the importance of drebrin-bound F-actin in neurons during early developmental stages of neurons in embryonic, postnatal, and adult brains. There are three major isoforms of drebrin in the chicken brain (E1, E2, and A) and two major isoforms in the mammalian brain (E and A). Among these drebrin isoforms, drebrin E1 and E2 in chicken and drebrin E in the mammalian brain are involved in these neuronal stages. In migrating neurons of the developing and adult brain, drebrin is localized at the base of filopodia of leading processes, to regulate neuronal migration. In axonal growth cones, drebrin is localized in the transitional zone to regulate axonal growth by inhibiting actomyosin interactions and mediating the interactions between F-actin and microtubules. For axonal collateral branching, drebrin is localized at axonal actin patches and the base of filopodia, to accelerate the transition from actin patches to filopodia and stabilize the filopodia.