Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis
Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis
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DOI：
10.1016/s0029-7844(97)00117-8
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发表时间：
1997-06-01
影响因子：
7.2
通讯作者：
Tomoda, Y
中科院分区：
文献类型：
--
作者：
Kikkawa, F;Ishikawa, H;Tomoda, Y
目的：卵巢成熟囊性畸胎瘤发生鳞状细胞癌的临床病理研究较少。因此，本研究的目的是确定影响生存的临床病理因素，在这种罕见的tumor.Methods：从1979年9月至1996年6月，37例鳞状细胞癌所产生的卵巢成熟囊性畸胎瘤治疗的东海卵巢肿瘤研究组。对这些患者进行回顾性临床病理和生存分析。浸润的模式分为膨胀，中度扩散，扩散patterns.Results：虽然5年生存率分别为94.7%和80.0%的I期和II期患者，分别为12 13例III期患者在20个月内死亡（P = 0.0001）。在手术时有和没有残留肿瘤的组之间也观察到了显著差异（P = 0.0001）。单因素分析显示，病理特征、分级、浸润方式和血管受累是影响预后的重要因素。多变量分析显示，与浸润级别（P = 0.0154）和浸润模式（P = 0.0053）相关的生存率存在显著差异。成熟性囊性畸胎瘤伴鳞状细胞癌患者术前抗原水平明显高于成熟性囊性畸胎瘤患者（P < .0001）。结论：本研究提示病理因素、分级和浸润方式可为预测成熟性囊性畸胎瘤伴鳞状细胞癌患者的生存提供有价值的信息。此外，鳞状细胞癌抗原可能是术前检测这种疾病的有用标志物。(C)1997年由美国妇产科医师学会。
Objective: There have been few studies concerning the clinical pathology of squamous cell carcinoma arising from ovarian mature cystic teratoma. Thus, the objective of this study is to determine clinicopathologic factors affecting survival in this rare tumor.Methods: From September 1979 to June 1996, 37 patients with squamous cell carcinoma arising from ovarian mature cystic teratoma were treated by the Tokai Ovarian Tumor Study Group. A retrospective clinicopathologic and survival analysis of these patients was performed. The mode of infiltration was classified into expansive, moderately diffused, and diffused patterns.Results: Although the 5-year survival rate was 94.7% and 80.0% for stage I and II patients, respectively, 12 of 13 patients with stage III died within 20 months (P = .0001). A significant difference was also observed between the survival of the groups with and without residual tumor at surgery (P = .0001). Pathologic features, grade, mode of infiltration, and vascular involvement were significant factors by univariate analysis. Multivariate analysis showed significant differences in survival related to grade (P = .0154) and mode of infiltration (P = .0053). The preoperative squamous cell carcinoma antigen level was significantly higher in the patients with squamous cell carcinoma arising from mature cystic teratoma than in patients with mature cystic teratoma (P < .0001).Conclusion: This study suggests that pathologic factors, grade, and mode of infiltration can provide valuable information for predicting the survival of patients with squamous cell carcinoma arising from mature cystic teratoma. In addition, squamous cell carcinoma antigen may be a useful marker to detect this disease preoperatively. (C) 1997 by The American College of Obstetricians and Gynecologists.