Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions.
Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions.
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系统性红斑狼疮 T 细胞亚群、抗 T 细胞抗体和 T 细胞功能之间的关系。
DOI：
10.1172/jci111261
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Schlossman,SF
中科院分区：
文献类型：
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作者：
Morimoto,C;Reinherz,EL;Distaso,JA;Steinberg,AD;Schlossman,SF
以往的研究表明，系统性红斑狼疮（SLE）患者有不同的T细胞T4+/T8+比值，该比值与疾病的临床特征相关。在本研究中，我们希望确定这些患者的外周血T细胞亚群是否与其血浆中发现的抗T细胞抗体的特异性有关。来自24名SLE患者的血浆与大于20%的正常T细胞反应，分析其对体外美洲商陆促分裂原刺激的免疫球蛋白合成的影响以及其与人T4+和T8+细胞的反应性。在SLE患者中发现的抗T细胞抗体具有一系列反应性。我们集中研究干扰抑制功能的抗体。一组SLE抗T细胞抗体优先与T8+抑制效应细胞反应，而另一组则与T4+抑制诱导亚群反应。T4+/T8+比值高的SLE患者的抗T细胞抗体主要与T8+抑制效应细胞反应。另一方面，T4+/T8+比值低的患者具有与T4+抑制诱导物或与T4+抑制诱导物和T8+抑制效应细胞反应的抗T细胞抗体。此外，还定义了第四组，其抗T细胞抗体既不与功能性T4+抑制诱导剂反应，也不与功能性T8+抑制效应细胞反应。这些患者外周血T细胞的循环T4+/T8+比值与其抗T细胞抗体杀伤T8+细胞与T4+细胞的相对能力之间存在显著相关性（γ = 0.666，P <0.001）。这些结果支持了这样的观点，即在SLE中，免疫调节回路中的不同细胞缺陷是自身免疫反应发展的基础，抗T细胞抗体可能导致T细胞亚群的数量和功能缺陷。图片
Previous studies have shown that patients with systemic lupus erythematosus (SLE) had differing T cell T4+/T8+ ratios and that the ratio correlated with clinical features of the disease. In the present study, we wished to determine whether the peripheral blood T cell subsets in these patients were related to the specificity of anti-T cell antibodies found in their plasma. Plasma from 24 SLE patients that reacted with greater than 20% of normal T cells were analyzed for their effect on in vitro pokeweed mitogen-stimulated immunoglobulin synthesis and for their reactivity with human T4+ and T8+ cells. Anti-T cell antibodies found in SLE patients have a spectrum of reactivities. We concentrated upon antibodies that interfere with suppressor function. One group of SLE anti-T cell antibodies reacts preferentially with the T8+ suppressor effector cell whereas another is reactive with T4+ suppressor inducer subsets. SLE patients with high T4+/T8+ ratios had anti-T cell antibodies predominantly reactive with the T8+ suppressor effector cells. Patients with low T4+/T8+ ratios, on the other hand, had anti-T cell antibodies reactive with either the T4+ suppressor inducer or with both the T4+ suppressor inducer and T8+ suppressor effector cells. In addition, a fourth group was defined whose anti-T cell antibodies were neither reactive with a functional T4+ suppressor inducer nor a functional T8+ suppressor effector cells. There was a significant correlation between the circulating T4+/T8+ ratio of peripheral T cells in these patients and the relative ability of their anti-T cell antibodies to kill T8+ cells vs. T4+ cells (gamma = 0.666, P less than 0.001). These results support the notion that in SLE different cellular defects in the immunoregulatory circuit underlie the development of autoimmune reactions and that the anti-T cell antibodies may cause numerical and functional deficiencies in T cell subsets.Images