Model systems for regeneration: Drosophila
Model systems for regeneration: Drosophila
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DOI：
10.1242/dev.173781
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发表时间：
2020-04-01
期刊：
影响因子：
4.6
通讯作者：
Smith-Bolton, Rachel
中科院分区：
文献类型：
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作者：
Fox, Donald T.;Cohen, Erez;Smith-Bolton, Rachel
黑腹果蝇在历史上一直是研究发育生物学的模式生物。此外，果蝇是研究受损组织和器官如何再生的绝佳模型。最近，能够实现高度靶向损伤和遗传操作的新的精确方法加速了这一领域的进展。在这里，我们强调这些技术和审查最近发现的机制，调节果蝇幼虫和成人组织再生的例子。我们还讨论了如何通过应用这些强大的方法，果蝇的研究可以继续指导再生研究的未来。
Drosophila melanogaster has historically been a workhorse model organism for studying developmental biology. In addition, Drosophila is an excellent model for studying how damaged tissues and organs can regenerate. Recently, new precision approaches that enable both highly targeted injury and genetic manipulation have accelerated progress in this field. Here, we highlight these techniques and review examples of recently discovered mechanisms that regulate regeneration in Drosophila larval and adult tissues. We also discuss how, by applying these powerful approaches, studies of Drosophila can continue to guide the future of regeneration research.