Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.
Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.
复制标题
疾病的关键时期和发育起源：精神分裂症的表观遗传学视角。
DOI：
10.1111/j.1749-6632.2010.05644.x
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发表时间：
2010
影响因子：
5.2
通讯作者：
Malaspina,Dolores
中科院分区：
文献类型：
--
作者：
Perrin,Mary;Kleinhaus,Karine;Messinger,Julie;Malaspina,Dolores
表观遗传学有望解释有关精神疾病风险和病程的一些谜题。表观遗传信息作为基因组的一套操作指令至关重要，可通过 DNA 遗传。基因表达的表观遗传调控可能受到祖先环境、产前暴露和早期生活事件的影响。一些表观遗传机制可能通过编程基因表达来改变整个生命过程中的神经生理学，也许是为了预期某些生活经历。这些表观遗传信号只是亚稳定的，可能会受到随机事件、错误或环境毒素的干扰。本文认为，随着父亲年龄的增长或胎儿逆境期间可能发生的表观遗传变化可能与精神分裂症的易感性存在因果关系。
Epigenetics holds promise to explain some puzzles concerning the risk and course of psychiatric disorders. Epigenetic information is essential as a set of operating instructions for the genome, which is heritable with DNA. The epigenetic regulation of gene expression can plausibly be influenced by the environment of one's ancestors, prenatal exposures, and by early life events. Some epigenetic mechanisms may alter neurophysiology throughout life by programming gene expression, perhaps in anticipation of certain life experiences. These epigenetic signals are only meta‐stable and may be perturbed by stochastic events, errors, or by environmental toxins. This introduction considers the possibility that epigenetic change that may occur as paternal age advances or during fetal adversity may be causally related to the susceptibility for schizophrenia.