Whole tissue AC susceptibility after superparamagnetic iron oxide contrast agent administration in a rat model
Whole tissue AC susceptibility after superparamagnetic iron oxide contrast agent administration in a rat model
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DOI：
10.1016/j.jmmm.2006.10.1168
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Munoz, Maria Jesus
中科院分区：
文献类型：
--
作者：
Lazaro, Francisco Jose;Gutierrez, Lucia;Munoz, Maria Jesus
在静脉注射超顺磁性氧化铁（Endorem(R)）后，对大鼠组织进行了交流磁化率表征，其剂量与人类磁共振成像（MRI）增强相同。测量结果显示造影剂以及生理性铁蛋白在肝脏和脾脏中存在，而在心脏和肾脏中没有磁检测到痕迹。这项初步工作为未来任何类型的磁性载体的生物分布研究提供了暗示的可能性。(C) 2006 Elsevier B.V.版权所有
A magnetic AC susceptibility characterisation of rat tissues after intravenous administration of superparamagnetic iron oxide (Endorem(R)), at the same dose as established for Magnetic Resonance Imaging (MRI) contrast enhancement in humans, has been carried out. The measurements reveal the presence of the contrast agent as well as that of physiological ferritin in liver and spleen while no traces have been magnetically detected in heart and kidney. This preliminary work opens suggestive possibilities for future biodistribution studies of any type of magnetic carriers. (C) 2006 Elsevier B.V. All rights reserved.