Fabrication of low-crystallinity hydroxyapatite foam based on the setting reaction of α-tricalcium phosphate foam
Fabrication of low-crystallinity hydroxyapatite foam based on the setting reaction of α-tricalcium phosphate foam
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DOI：
10.1002/jbm.a.31904
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发表时间：
2009-03-01
影响因子：
4.9
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Karashima, Satoshi;Takeuchi, Akari;Ishikawa, Kunio
低结晶度羟基磷灰石（HAP）泡沫是一种理想的骨替代材料和骨组织再生支架材料，其内部的孔隙为细胞生长和组织渗透提供了空间，其组成具有良好的组织反应性和骨传导性。本研究基于α-磷酸三钙（alpha-TCP）泡沫颗粒的相变反应或所谓的溶解-再沉淀反应来评估低结晶度HAP泡沫制造的可行性。当将α-TCP泡沫颗粒置于37 ℃的水中1天时，没有观察到反应。然而，α-TCP泡沫颗粒通过在200摄氏度下水热处理而形成低结晶度HAP。保留了完全互连的孔隙网络，孔隙率高达82%。孔径范围为50至300 μ m，平均孔径为160 μ m。抗压强度为207 kPa。虽然在37 ℃下没有观察到固化反应，但由a-TCP泡沫颗粒的水热处理引起的固化反应允许制造任何形状的低结晶度HAP。因此，这种方法可能是有用的骨组织再生的骨替代品和支架的制造。(c)2008 Wiley Periodicals，Inc. J Biomed Mater Res 88A：628-633，2009
Low-crystallinity hydroxyapatite (HAP) foam is an ideal material for bone substitutes and scaffolds for bone tissue regeneration, because its interconnected pores provide the space for cell growth and tissue penetration, and its composition induces excellent tissue response and good osteoconductivity. In this Study, the feasibihty of low-crystallinity HAP foam fabrication was evaluated based on the phase transformation reaction or the so-called dissolution-reprecipitation reaction of a-tricalcium phosphate (alpha-TCP) foam granules. When alpha-TCP foam granules were placed in water at 37 degrees C for 1 day, no reaction was observed. However, alpha-TCP foam granules set to form low-crystallinity HAP by treating it hydrothermally at 200 degrees C. The network of fully interconnected pores was retained, and porosity was as high as 82%. Pore size ranged from 50 to 300 mu m with an average pore size of 160 mu m. Compressive strength was 207 kPa. Although no setting reaction was observed at 37 degrees C, the setting reaction caused by the hydrothermal treatment of alpha-TCP foam granules allowed the fabrication of any shape of low-crystallinity HAP. Therefore, this method may be useful for the fabrication of bone substitutes and scaffolds in bone tissue regeneration. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 628-633, 2009