Chromosomal aberrations induced by cobaltous chloride in mice in vivo
Chromosomal aberrations induced by cobaltous chloride in mice in vivo
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氯化钴诱导小鼠体内染色体畸变
DOI：
10.1007/bf03032691
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发表时间：
1991
影响因子：
3.9
通讯作者：
G. Talukder
中科院分区：
文献类型：
--
作者：
S. Palit;Archana Sharma;G. Talukder
本文观察了氯化钴致死毒性剂量(1/10、1/20、1/40)的不同级分(1/10、1/20、1/40)对小鼠体内诱发染色体畸变的影响。骨髓细胞在秋水仙碱、低渗、吉姆萨、风干等步骤后被冲出并进行染色体研究。筛选的参数是染色体畸变率，每个细胞有和没有缝隙和断裂。在6、12、18和24小时后对玻片进行筛选。统计分析表明盐的碎裂作用。染色体损伤程度与染毒浓度直接相关，也与染毒后时间长短有关。细胞周期的不同阶段受到影响。
The effects of cobaltous chloride in inducing chromosomal aberrations were observed on laboratory bred mice in vivo after single oral administration of different fractions (1/10, 1/20, 1/40) of the lethal toxic dose of the salt. Bone marrow cells were flushed out and processed for chromosome studies following colchicine, hypotonic, giemsa, air drying procedure. The parameters screened were chromosomal aberrations, with and without gaps and break per cell. Slides were screened after the expiry of 6, 12, 18, and 24 h. Statistical analysis indicated the clastogenic effects of the salt. The degree of chromosome damage was directly related to the concentration, and also to the period after administration. The different stages of the cell cycle were affected.