Neuroscience and Biobehavioral Reviews the Neural Mechanisms of Hallucinations: a Quantitative Meta-analysis of Neuroimaging Studies
Neuroscience and Biobehavioral Reviews the Neural Mechanisms of Hallucinations: a Quantitative Meta-analysis of Neuroimaging Studies
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通讯作者：
Leor Zmigrod;Jane R. Garrison;Joseph Carr;J. S. Simons;J. S. Simons
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作者：
Leor Zmigrod;Jane R. Garrison;Joseph Carr;J. S. Simons;J. S. Simons
保留字：幻觉听觉言语视觉ALE荟萃分析现实监测a B s t t功能神经成像数据的激活可能性估计荟萃分析用于研究听觉言语和视觉幻觉（AVH和VH）的神经机制。一致的激活跨研究期间AVHS，但不是VHS，在韦尼克和布罗卡的领域是一致的参与语音和语言过程的经验，听到的声音时，没有存在。类似地，在AVHS期间听觉皮层和在VHS期间视觉皮层的更大活动支持提出在这些感知异常的产生中过度刺激感觉皮层的模型。在内侧颞叶的激活跨研究强调了记忆入侵的作用，在提供内容AVH，而ESTA激活可能涉及到的意识和自我表征的参与。最后，激活在内侧前额叶皮层的副扣带区AVHS是一致的模型，暗示现实监测障碍的错误归因的自我生成的信息作为外部感知。根据研究结果，需要统一的理论框架，占全方位的幻觉经验进行了讨论。
Keywords: Hallucinations Auditory-verbal Visual ALE meta-analysis Reality monitoring a b s t r a c t Activation likelihood estimation meta-analysis of functional neuroimaging data was used to investigate the neural mechanisms underlying auditory-verbal and visual hallucinations (AVHs and VHs). Consistent activation across studies during AVHs, but not VHs, in Wernicke's and Broca's areas is consistent with involvement of speech and language processes in the experience of hearing voices when none are present. Similarly, greater activity in auditory cortex during AVHs and in visual cortex during VHs supports models proposing over-stimulation of sensory cortices in the generation of these perceptual anomalies. Activation across studies in the medial temporal lobe highlights a role for memory intrusions in the provision of content for AVHs, whereas insula activation may relate to the involvement of awareness and self-representation. Finally, activation in the paracingulate region of medial prefrontal cortex during AVHs is consistent with models implicating reality monitoring impairment in the misattribution of self-generated information as externally perceived. In the light of the results, the need for unified theoretical frameworks that account for the full range of hallucinatory experiences is discussed.