Central processing of leg proprioception in Drosophila.
Central processing of leg proprioception in Drosophila.
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DOI：
10.7554/elife.60299
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发表时间：
2020-12-02
期刊：
影响因子：
7.7
通讯作者：
Tuthill JC
中科院分区：
文献类型：
--
作者：
Agrawal S;Dickinson ES;Sustar A;Gurung P;Shepherd D;Truman JW;Tuthill JC
本体感觉，即自我运动和位置的感觉，由检测身体运动学的不同特征的机械感觉神经元介导。虽然本体感觉反馈对于精确的运动控制至关重要，但是关于下游回路如何转换肢体感觉信息以指导运动输出知之甚少。在这里，我们研究果蝇的神经回路，处理来自蝇腿的本体感受信息。我们从不同的发育谱系中确定了三种细胞类型，它们被定位为接收编码胫骨位置、运动和振动的本体感受器亚型的输入。13 B α神经元编码股骨-胫骨关节角并介导胫骨位置的姿势变化。9Aα神经元也驱动腿部姿势的变化，但编码定向运动，高频振动和关节角度的组合。激活编码特定关节角度胫骨振动的10 B α神经元，在行走的苍蝇中产生elevently停顿。总而言之，我们的研究结果表明，中央回路整合本体感受器亚型的信息，构建复杂的感觉运动表征，介导不同的行为，包括肢体姿势的反射控制和腿部振动的检测。
Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features of body kinematics. Although proprioceptive feedback is crucial for accurate motor control, little is known about how downstream circuits transform limb sensory information to guide motor output. Here we investigate neural circuits in Drosophila that process proprioceptive information from the fly leg. We identify three cell types from distinct developmental lineages that are positioned to receive input from proprioceptor subtypes encoding tibia position, movement, and vibration. 13Bα neurons encode femur-tibia joint angle and mediate postural changes in tibia position. 9Aα neurons also drive changes in leg posture, but encode a combination of directional movement, high frequency vibration, and joint angle. Activating 10Bα neurons, which encode tibia vibration at specific joint angles, elicits pausing in walking flies. Altogether, our results reveal that central circuits integrate information across proprioceptor subtypes to construct complex sensorimotor representations that mediate diverse behaviors, including reflexive control of limb posture and detection of leg vibration.