Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and a case-control approach.
Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and a case-control approach.
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DOI：
10.1021/es503653n
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发表时间：
2015-02
影响因子：
11.4
通讯作者：
Anna Rotander;Anna Kärrman;L. Toms;M. Kay;Jochen F Mueller;María José Gómez Ramos
中科院分区：
文献类型：
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作者：
Anna Rotander;Anna Kärrman;L. Toms;M. Kay;Jochen F Mueller;María José Gómez Ramos
氟化表面活性剂水基成膜泡沫（AFFF）由全氟和多氟烷基物质（PFAS）组成，用于扑灭涉及高度易燃液体的火灾。在一些水成膜泡沫配方中使用全氟辛烷磺酸和其他全氟烷基酸已被认为与严重的环境污染有关。最近的研究已经在不同的AFFF配方中确定了大量新颖且不常报道的氟化表面活性剂。在这项研究中，一个策略的基础上的病例对照方法，使用四极杆飞行时间串联质谱（QTOF-MS/MS）和先进的统计方法已被用来提取和识别已知和未知的PFAS在人类血清与AFFF暴露的消防员。与对照组相比，消防员体内检测到的两种目标磺酸[全氟辛烷磺酸和全氟己烷磺酸（PFHxS）]、三种非目标酸[全氟戊烷磺酸（PFPeS）、全氟庚烷磺酸（PFHpS）和全氟壬磺酸（PFNS）]以及四种未知磺酸（Cl-PFOS、酮-PFOS、醚-PFHxS和Cl-PFHxS）的浓度水平较高，或明显较高。通过采用这一战略，可以及时和具有成本效益地查明以前未报告的含氟化学品。
Fluorinated surfactant-based aqueous film-forming foams (AFFFs) are made up of per- and polyfluorinated alkyl substances (PFAS) and are used to extinguish fires involving highly flammable liquids. The use of perfluorooctanesulfonic acid (PFOS) and other perfluoroalkyl acids (PFAAs) in some AFFF formulations has been linked to substantial environmental contamination. Recent studies have identified a large number of novel and infrequently reported fluorinated surfactants in different AFFF formulations. In this study, a strategy based on a case-control approach using quadrupole time-of-flight tandem mass spectrometry (QTOF-MS/MS) and advanced statistical methods has been used to extract and identify known and unknown PFAS in human serum associated with AFFF-exposed firefighters. Two target sulfonic acids [PFOS and perfluorohexanesulfonic acid (PFHxS)], three non-target acids [perfluoropentanesulfonic acid (PFPeS), perfluoroheptanesulfonic acid (PFHpS), and perfluorononanesulfonic acid (PFNS)], and four unknown sulfonic acids (Cl-PFOS, ketone-PFOS, ether-PFHxS, and Cl-PFHxS) were exclusively or significantly more frequently detected at higher levels in firefighters compared to controls. The application of this strategy has allowed for identification of previously unreported fluorinated chemicals in a timely and cost-efficient way.