THE INCIDENCE AND NATURAL-HISTORY OF KNEE OSTEOARTHRITIS IN THE ELDERLY - THE FRAMINGHAM OSTEOARTHRITIS STUDY
THE INCIDENCE AND NATURAL-HISTORY OF KNEE OSTEOARTHRITIS IN THE ELDERLY - THE FRAMINGHAM OSTEOARTHRITIS STUDY
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DOI：
10.1002/art.1780381017
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发表时间：
1995-10-01
影响因子：
--
通讯作者：
LEVY, D
中科院分区：
文献类型：
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作者：
FELSON, DT;ZHANG, YQ;LEVY, D
目的：了解膝关节骨性关节炎（OA）的影像学表现及症状性OA的发生率（症状加放射学GA），以及在基于人群的老年人样本中预先存在的放射学OA的进展率，方法，1983-1985年接受膝关节X光片检查并回答有关膝关节症状问题的受试者在1992-1993年接受复查（平均间隔8.1年）使用相同的方案，受试者被定义为有新的（事件）放射学OA，如果他们发展等级大于或等于2 OA（至少明确的骨赘或明确的关节间隙狭窄），如果受试者出现膝关节症状和≥ 2级OA的组合，则存在新发症状性OA，当基线时显示2级疾病的X光片在随访时显示大于或等于3级疾病时，诊断为进行性OA。（26.9%）在随访前死亡，在1，051名存活受试者中，869名（82.7%）参加了随访研究（基线时平均+/- SD年龄为70.8 +/- 5.0），女性的发病率是男性的1.7倍（95%置信区间[CI] 1.0-2.7），女性患者的疾病进展率略高（相对危险度= 1.4; 95%CI 0.8-2.5），但在该样本中，发生率不随年龄变化。在女性中，每年约有2%的人发生放射学疾病，每年约有1%的患者发生症状性膝关节OA，每年约有4%的患者发生进展性膝关节OA。结论：在老年人中，新发膝关节OA较常见，且女性多于男性，但在老年人中，年龄可能并不影响新发疾病的发生或进展。
Objective, To determine the incidence of radiographic knee osteoarthritis (OA) and symptomatic OA (symptoms plus radiographic GA), as well as the rate of progression of preexisting radiographic OA in a population-based sample of elderly persons,Methods, Framingham Osteoarthritis Study subjects who had knee radiographs and had answered questions about knee symptoms in 1983-1985 were reexamined in 1992-1993 (mean 8,1-year interval) using the same protocol, Subjects were defined as having new (incident) radiographic OA if they developed grade greater than or equal to 2 OA (at least definite osteophytes or definite joint space narrowing), New symptomatic OA was present if subjects developed a combination of knee symptoms and grade greater than or equal to 2 OA, Progressive OA was diagnosed when radiographs showing grade 2 disease at baseline showed grade greater than or equal to 3 disease on followup.Results, Of 1,438 participants in the original study, 387 (26.9%) died prior to followup, Of the 1,051 surviving subjects, 869 (82.7%) participated in the followup study (mean +/- SD age 70.8 +/- 5.0 at baseline), Rates of incident disease were 1.7 times higher in women than in men (95% confidence interval [CI] 1.0-2.7), and progressive disease occurred slightly more often in women (relative risk = 1.4; 95% CI 0.8-2.5) but rates did not vary by age in this sample, Among women, approximately 2% per year developed incident radiographic disease, 1% per year developed symptomatic knee OA, and about 4% per year experienced progressive. knee OA,Conclusion, In elderly persons, the new onset of knee OA is frequent and is more common in women than men, However, among the elderly, age may not affect new disease occurrence or progression.