Motor cortex stimulation in patients with Parkinson disease: 12-month follow-up in 4 patients
Motor cortex stimulation in patients with Parkinson disease: 12-month follow-up in 4 patients
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DOI：
10.3171/jns/2008/109/7/0133
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发表时间：
2008-07-01
影响因子：
4.1
通讯作者：
Shils, Jay L.
中科院分区：
文献类型：
--
作者：
Arle, Jeffrey E.;Apetauerova, Diana;Shils, Jay L.
Object.自Tsubokawa等人1991年首次报告以来，刺激皮层的M1区域已被用于治疗慢性疼痛状况和各种运动障碍。对1991年至2007年初发表的文献进行Medline检索，发现459例使用运动皮层刺激（MCS）的病例。其中，72例与运动障碍有关。最近，多达16名帕金森病患者接受了MCS治疗，并报告了各种结果。在这份报告中，作者描述了4例患者谁是硬膜外MCS治疗。虽然在前6个月内在统一帕金森病评定量表第三部分评分中观察到了益处（降低了60%），但在该组中MCS仅对震颤进行了适度管理，并且最初观察到的大多数益处在12个月结束时消失。尽管MCS治疗帕金森病有一些积极的发现，但可能需要进行更大规模的研究，以更好地确定是否应将其作为DBS的替代手术治疗。
Object. Since the initial 1991 report by Tsubokawa et al., stimulation of the M1 region of cortex has been used to treat chronic pain conditions and a variety of movement disorders.Methods. A Medline search of the literature published between 1991 and the beginning of 2007 revealed 459 cases in which motor cortex stimulation (MCS) was used. Of these, 72 were related to a movement disorder. More recently, up to 16 patients specifically with Parkinson disease were treated with MCS, and a variety of results were reported. In this report the authors describe 4 patients who were treated with extradural MCS.Results. Although there were benefits seen within the first 6 months in Unified Parkinson's Disease Rating Scale Part III scores (decreased by 60%), tremor was only modestly managed with MCS in this group, and most benefits seen initially were lost by the end of 12 months.Conclusions. Although there have been some positive findings using MCS for Parkinson disease, a larger study may be needed to better determine if it should be pursued as an alternative surgical treatment to DBS.