Dyslipidemia in Granuloma Annulare A Case-Control Study
Dyslipidemia in Granuloma Annulare A Case-Control Study
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DOI：
10.1001/archdermato1.2012.1381
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发表时间：
2012-10-01
影响因子：
--
通讯作者：
Kroumpouzos, George
中科院分区：
文献类型：
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作者：
Wu, Wesley;Robinson-Bostom, Leslie;Kroumpouzos, George
目的：估计特发性环状肉芽肿患者中血脂异常（DLP）的患病率，并研究其与疾病特征和合并症（如代谢综合征）的关系。设计：病例对照研究，使用2002年1月至2010年12月的医疗记录。环境：大学医院和医疗保健系统。参与者：由140名患者和420名年龄、性别、种族/民族、高血压、2型糖尿病和甲状腺功能减退相匹配的个体组成的成年人。主要结局指标：特发性环状肉芽肿中DLP及其相关成分（高胆固醇血症、高甘油三酯血症、低密度脂蛋白胆固醇升高、低高密度脂蛋白胆固醇升高）的患病率，以及校正混杂变量后DLP的优势比。结果：环形肉芽肿组DLP患病率为79.3%，对照组为51.9% （P < 0.001）。调整混杂变量后，环形肉芽肿与DLP相关（优势比4.04;95% Cl, 2.53-6.46）。总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平在患者和对照组之间存在统计学上的显著差异（所有变量的P < 0.001）。疾病程度与DLP之间有统计学意义的相关性（P = 0.02）。环形病变形态与高胆固醇血症（P = 0.02）和DLP （P = 0.01）相关。结论：本研究表明环形肉芽肿与DLP之间存在关联。血脂异常在全身性疾病中比在局部/播散性疾病中更常见，环形病变形态与高胆固醇血症和DLP相关。医生应该意识到这些重要的关联，并在处理环形肉芽肿时考虑它们。
Objectives: To estimate the prevalence of dyslipidemia (DLP) among individuals with idiopathic granuloma annulare and to examine associations with disease characteristics and comorbidities, such as metabolic syndrome.Design: Case-control study using review of medical records from January 2002 through December 2010.Setting: A university hospital and a health care system.Participants: Adults consisting of 140 patients and 420 individuals serving as controls matched for age, sex, race/ethnicity, hypertension, type 2 diabetes mellitus, and hypothyroidism.Main Outcome Measures: Prevalence of DLP and its associated components (hypercholesterolemia, hypertriglyceridemia, elevated low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol) in idiopathic granuloma annulare, as well as odds ratio of DLP after adjusting for confounding variables.Results: The prevalence of DLP was 79.3% among granuloma annulare cases and 51.9% among controls (P < .001). Granuloma annulare was associated with DLP (odds ratio, 4.04; 95% Cl, 2.53-6.46) after adjusting for confounding variables. Statistically significant differences between patient and control groups were found for levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P < .001 for all variables). A statistically significant association between the extent of disease and DLP (P = .02) was shown. Annular lesion morphology was associated with hypercholesterolemia (P = .02) and DLP (P = .01).Conclusions: This study indicates an association between granuloma annulare and DLP. Dyslipidemia is more common in generalized than in localized/disseminated disease, and the annular lesion morphology is associated with hypercholcstcrolemia and DLP. Physicians should be aware of these important associations and consider them in the management of granuloma annulare.