Impact of Nutritional Supplementation and a Psychomotor Program on Patients With Alzheimer's Disease
Impact of Nutritional Supplementation and a Psychomotor Program on Patients With Alzheimer's Disease
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DOI：
10.1177/1533317517705221
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发表时间：
2017-09-01
影响因子：
3.4
通讯作者：
Amaral, Teresa Freitas
中科院分区：
文献类型：
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作者：
de Sousa, Odete Vicente;Guerra, Rita Soares;Amaral, Teresa Freitas
本研究旨在评估口服营养补充(ONS)和精神运动康复计划对社区阿尔茨海默病(AD)患者营养和功能状况的影响。进行为期21天的前瞻性随机对照试验，第三干预组实施精神运动康复计划。对患者进行180天的随访。营养补充组(NSG；n=25)、精神运动康复计划组(NSPRG；n=11)、精神运动康复计划组(CG；n=43)的MNA均分(标准差)分别增加0.4(0.8)、1.5(1.0)和-0.1(1.1)，P<；0.05。NSG组：1.3(1.2)和NSPRG组：1.6(1.0)比CG(P<；0.05)的0.3(1.7)在90天的随访期有进一步的改善。一般线性模型分析显示，干预后21天和90天的NSG和NSPRG MNA评分的改善与基线时的MNA和Mini-State检查分数无关(P>；0.05)。国家统计局和精神运动康复计划对AD患者的长期营养和功能状态有积极的影响。
This study aims to evaluate the impact of oral nutritional supplementation (ONS) and a psychomotor rehabilitation program on nutritional and functional status of community-dwelling patients with Alzheimer's disease (AD). A 21-day prospective randomized controlled trial was conducted and third intervention group performed a psychomotor rehabilitation program. Patients were followed up for 180 days. Mean (standard deviation) score of Mini Nutritional Assessment (MNA) increased both in the nutritional supplementation group (NSG; n = 25), 0.4 (0.8), and in the nutritional supplementation psychomotor rehabilitation program group (NSPRG; n = 11), 1.5 (1.0), versus -0.1 (1.1) in the control group (CG; n = 43), P < .05. Further improvements at 90-day follow-up for MNA in NSG: 1.3 (1.2) and NSPRG: 1.6 (1.0) versus 0.3 (1.7) in CG (P < .05) were observed. General linear model analysis showed that the NSG and NSPRG MNA score improved after intervention, at 21 days and 90 days, was independent of the MNA and Mini-Mental State Examination scores at baseline (Ps > .05). The ONS and a psychomotor rehabilitation program have a positive impact on long-term nutritional and functional status of patients with AD.