On the origin of mitochondria:: a genomics perspective
On the origin of mitochondria:: a genomics perspective
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DOI：
10.1098/rstb.2002.1193
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发表时间：
2003-01-29
影响因子：
6.3
通讯作者：
Kurland, CG
中科院分区：
文献类型：
--
作者：
Andersson, SGE;Karlberg, O;Kurland, CG
来自细菌和真核生物的完整基因组序列数据的可用性提供了关于细菌基因对线粒体起源和进化的贡献的信息。基于位于线粒体基因组中的基因的系统发育分析表明，这些基因起源于α-变形菌。许多祖先细菌基因也已经从线粒体转移到核基因组，如在一些物种的线粒体基因组和其他物种的核基因组中存在正向同源基因所证明的。然而，在细胞核中编码的大量线粒体蛋白与细菌蛋白没有同源性，表明这些蛋白起源于内共生体获得后的真核细胞内。对编码线粒体蛋白的酵母核基因的表达模式的分析表明，预测为真核生物来源的基因主要在胞质溶胶中游离的多聚核糖体上翻译，而那些推定的细菌来源的基因在附着于线粒体的多聚核糖体上翻译。与α-proteobacteria基因观察到的一些线粒体基因的强相关性，结合缺乏这样的关系，为其他人，表明现代线粒体蛋白质组是还原和膨胀过程的产物。
The availability of complete genome sequence data from both bacteria and eukaryotes provides information about the contribution of bacterial genes to the origin and evolution of mitochondria. Phylogenetic analyses based on genes located in the mitochondrial genome indicate that these genes originated from within the alpha-proteobacteria. A number of ancestral bacterial genes have also been transferred from the mitochondrial to the nuclear genome, as evidenced by the presence of orthologous genes in the mitochondrial genome in some species and in the nuclear genome of other species. However, a multitude of mitochondrial proteins encoded in the nucleus display no homology to bacterial proteins, indicating that these originated within the eukaryotic cell subsequent to the acquisition of the endosymbiont. An analysis of the expression patterns of yeast nuclear genes coding for mitochondrial proteins has shown that genes predicted to be of eukaryotic origin are mainly translated on polysomes that are free in the cytosol whereas those of putative bacterial origin are translated on polysomes attached to the mitochondrion. The strong relationship with alpha-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes.