Automated chemical synthesis: From resins to instruments
Automated chemical synthesis: From resins to instruments
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DOI：
10.1007/bf01715635
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发表时间：
1997-04-01
影响因子：
3.8
通讯作者：
Wright, P
中科院分区：
文献类型：
--
作者：
Porco, JA;Deegan, T;Wright, P
固相有机合成是目前药物发现中的一个普遍活动。与这种强烈的兴趣保持一致的是需要开发可靠的自动化合成仪器以及适用于全范围有机合成应用的聚合物载体和连接体。在本文中，我们回顾了我们在开发自动化化学合成新工具方面的活动，包括：（i）新的固体支持物，如ArgoGel（TM）（基于PS-PEG）和Argo-X203（基于PS）;和（ii）Nautilus（TM）2400系统，一个全封闭和惰性的自动化化学开发工作站。将描述在Nautilus和新的固体支持物上进行的选定化学优化和合成实例。
Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such as ArgoGel(TM) (PS-PEG-based) and Argo-X203 (PS-based); and (ii) the Nautilus(TM) 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.