Adenosine deaminase polymorphism in man
Adenosine deaminase polymorphism in man
复制标题
人类腺苷脱氨酶多态性
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
H. Harris
中科院分区：
文献类型：
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作者：
N. Spencer;D. Hopkinson;H. Harris
1介绍了一种研究腺苷脱氨酶同工酶的新的、特异的方法。2对红细胞裂解产物的检测揭示了三种不同的遗传决定的ADA表型：AdA 1，ADA 2-1和ADA 2。3家族研究表明，这些表型是由常染色体上的两个等位基因ADA1和ADA2决定的。4初步人口数据显示，ADA2在欧洲人中的频率约为0.06，在黑人中约为0.04，在亚洲印第安人中约为0.11。5硫醇试剂贮藏或处理后的ADA同工酶图谱表明，酶分子中存在反应性的巯基。
1 A new and specific method for the study of adenosine deaminase isozymes is described. 2 Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. 3 Family studies indicate that these phenotypes are determined by two alleles, ADA1 and ADA2 at an autosomal locus. 4 Preliminary population data suggest that ADA2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. 5 The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules.