Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia
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DOI：
10.1002/hbm.20412
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发表时间：
2008-04-01
影响因子：
4.8
通讯作者：
Panteliss, Christos
中科院分区：
文献类型：
--
作者：
Fornito, Alex;Yucel, Murat;Panteliss, Christos
前扣带皮层（ACC）似乎与精神分裂症的病理生理学密切相关，但过去使用磁共振成像表征该区域病理变化的尝试受到对其功能和解剖多样性的有限了解以及依赖相对粗略的指标（例如体积）来索引解剖变化的限制。在这项研究中，我们对 40 名首发精神分裂症患者和 40 名健康对照组的 T1 加权扫描应用了一种新颖的基于表面的方案，这些扫描分别匹配年龄、性别和副扣带沟的形态，这是一种主要的解剖变异，已被证明会影响该区域的形态测量估计。基于表面的方法能够以亚毫米精度计算区域灰质体积、表面积和曲率、皮质厚度和扣带沟深度。与对照组相比，精神分裂症患者双侧 ACC 旁边缘区域的厚度减少，同时边缘系统和旁边缘 ACC 的表面积也随之增加。区域灰质体积、表面曲率或 CS 深度没有差异。这些发现说明了在研究皮质形态测量时超越传统基于体积的方法的优势，并表明精神分裂症的早期阶段与 ACC 异常的特定模式相关，而这种异常模式不能归因于脑沟和脑回形态的变化。
The anterior cingulate cortex (ACC) appears to be critically involved in the pathophysiology of schizophrenia, but past attempts at characterizing pathological changes in the region using magnetic resonance imaging have been restricted by a limited appreciation of its functional and anatomical diversity and a reliance on relatively coarse metrics (e.g., volume) to index anatomical change. In this study, we applied a novel, surface-based protocol to T1-weighted scans acquired from 40 first episode schizophrenia patients and 40 healthy controls individually matched for age, sex, and morphology of the paracingulate sulcus, a major anatomical variation that has been shown to affect morphometric estimates in the region. The surface-based approach enabled calculation of regional grey matter volume, surface area and curvature, cortical thickness, and depth of the cingulate sulcus, with sub-millimeter precision. Relative to controls, schizophrenia patients displayed a bilateral reduction in thickness of paralimbic regions of the ACC, along with a concomitant increase in surface area of both the limbic and paralimbic ACC. No differences were identified for regional grey matter volume, surface curvature, or CS depth. These findings illustrate the advantages of moving beyond traditional volume-based approaches when investigating cortical morphometry, and indicate that the early stages of schizophrenia are associated with a specific pattern of ACC abnormalities that cannot be attributed to variations in sulcal and gyral morphology.