MERS-CoV recombination: implications about the reservoir and potential for adaptation.
MERS-CoV recombination: implications about the reservoir and potential for adaptation.
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DOI：
10.1093/ve/vev023
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发表时间：
2016-01
期刊：
影响因子：
5.3
通讯作者：
Rambaut A
中科院分区：
文献类型：
--
作者：
Dudas G;Rambaut A
重组是一个分离相邻基因的过程，允许许多生物体基因组中独立的进化轨迹。如果没有得到适当的解释，重组可能会危及许多进化分析。此外，在处理非强制性有性繁殖的有机体时，重组可以洞察不同的基因谱系接触的速度。自2012年6月以来，中东呼吸综合征冠状病毒(MERS-CoV)已造成1106例经实验室确认的感染，截至2015年4月16日，有421例与MERS-CoV相关的死亡。尽管蝙蝠被认为可能是人畜共患β冠状病毒的最终来源，但单峰骆驼一直被认为是目前中东地区人类感染的来源。在这篇文章中，我们使用系统发育方法和模拟来表明MERS-CoV基因组最近可能经历了多次重组。MERS冠状病毒的重组意味着MERS冠状病毒与不同谱系的MERS冠状病毒频繁合并感染，考虑到目前对MERS冠状病毒流行病学的理解，很可能是在骆驼中。
Recombination is a process that unlinks neighboring loci allowing for independent evolutionary trajectories within genomes of many organisms. If not properly accounted for, recombination can compromise many evolutionary analyses. In addition, when dealing with organisms that are not obligately sexually reproducing, recombination gives insight into the rate at which distinct genetic lineages come into contact. Since June 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused 1,106 laboratory-confirmed infections, with 421 MERS-CoV-associated deaths as of 16 April 2015. Although bats are considered as the likely ultimate source of zoonotic betacoronaviruses, dromedary camels have been consistently implicated as the source of current human infections in the Middle East. In this article, we use phylogenetic methods and simulations to show that MERS-CoV genome has likely undergone numerous recombinations recently. Recombination in MERS-CoV implies frequent co-infection with distinct lineages of MERS-CoV, probably in camels given the current understanding of MERS-CoV epidemiology.