Selective lesion of the hippocampus increases the differentiation of immature neurons in the monkey amygdala
Selective lesion of the hippocampus increases the differentiation of immature neurons in the monkey amygdala
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DOI：
10.1073/pnas.1604288113
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发表时间：
2016-12-13
影响因子：
11.1
通讯作者：
Lavenex, Pierre
中科院分区：
文献类型：
--
作者：
Chareyron, Loic J.;Amaral, David G.;Lavenex, Pierre
在成年灵长类动物杏仁核的腹内侧部分存在大量未成熟的神经元，该区域接受海马形成的大量直接投射。在这里，我们展示了新生儿（n = 8）和成年（n = 6）海马病变对成年猴杏仁核的线旁核、外侧核和基底核中成熟和未成熟神经元数量的影响。与未手术对照（n = 7）相比，新生儿和成年损伤猴的线旁核成熟神经元数量增加约70%，新生儿损伤猴的侧核和基核成熟神经元数量增加约40%。幼猴的未成熟神经元数量比幼猴高40%，而成年猴的未成熟神经元数量比幼猴低30%。在两只非实验性、选择性、双侧海马损伤的猴子身上也发现了类似的神经元数量变化。海马损伤后神经元数量的变化似乎反映了平行核中未成熟神经元的分化。成人病变后，未成熟神经元的分化基本上局限于层旁核，并与未成熟神经元数量的减少有关。相反，在新生儿病变后，未成熟神经元的分化涉及线旁核、外侧核和基底核。它与层旁核中未成熟神经元数量的增加有关。这种病变诱导的神经元可塑性为促进局灶性脑损伤后功能恢复的潜在机制提供了新的线索。
A large population of immature neurons is present in the ventromedial portion of the adult primate amygdala, a region that receives substantial direct projections from the hippocampal formation. Here, we show the effects of neonatal (n = 8) and adult (n = 6) hippocampal lesions on the populations of mature and immature neurons in the paralaminar, lateral, and basal nuclei of the adult monkey amygdala. Compared with unoperated controls (n = 7), the number of mature neurons was about 70% higher in the paralaminar nucleus of neonate- and adult-lesioned monkeys, and 40% higher in the lateral and basal nuclei of neonate-lesioned monkeys. The number of immature neurons in the paralaminar nucleus was 40% higher in neonate-lesioned monkeys and 30% lower in adult-lesioned monkeys. Similar changes in neuron numbers were also found in two monkeys with nonexperimental, selective, bilateral hippocampal damage. These changes in neuron numbers following hippocampal lesions appear to reflect the differentiation of immature neurons present in the paralaminar nucleus. After adult lesions, the differentiation of immature neurons was essentially restricted to the paralaminar nucleus and was associated with a decrease in the population of immature neurons. In contrast, after neonatal lesions, the differentiation of immature neurons involved the paralaminar, lateral, and basal nuclei. It was associated with an increase in the population of immature neurons in the paralaminar nucleus. Such lesion-induced neuronal plasticity sheds new light on potential mechanisms that may facilitate functional recovery following focal brain injury.