Dark therapy for mania: a pilot study
Dark therapy for mania: a pilot study
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DOI：
10.1111/j.1399-5618.2004.00166.x
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发表时间：
2005-02-01
影响因子：
5.4
通讯作者：
Smeraldi, E
中科院分区：
文献类型：
--
作者：
Barbini, B;Benedetti, F;Smeraldi, E
背景资料：最近的研究结果表明，延长卧床休息和黑暗可以稳定快速循环双相patients.Method的情绪波动：我们暴露了16双相住院患者的躁狂发作的方案，14小时的强制黑暗从下午6时至上午8时，每晚连续三天[黑暗疗法（DT）]。采用Young Mania Rating Scale（YMRS）量表记录患者的情绪变化模式，并与对照组（16例年龄、性别、发病年龄、既往发作次数和当前发作持续时间相匹配的住院患者）进行比较，对照组患者接受常规治疗（TAU）。当患者在当前躁狂发作后2周内接受治疗时，将DT添加到TAU导致YMRS评分显著更快下降。当当前发作持续时间较长时，DT无影响。随访证实，良好的反应需要一个较低剂量的抗躁狂药物和出院较早从hospital.Conclusions：时间生物学干预和控制环境刺激可以是一个有用的附加治疗急性躁狂症在医院设置。
Background: Recent findings suggest that extended bed rest and darkness could stabilize mood swings in rapid cycling bipolar patients.Method: We exposed 16 bipolar inpatients affected by a manic episode to a regimen of 14 h of enforced darkness from 6 p.m. to 8 a.m. each night for three consecutive days [dark therapy (DT)]. Pattern of mood changes were recorded with the Young Mania Rating Scale (YMRS) and compared with a control group of 16 inpatients matched for age, sex, age at onset, number of previous illness episodes and duration of current episode, and were treated with therapy as usual (TAU).Results: Adding DT to TAU resulted in a significantly faster decrease of YMRS scores when patients were treated within 2 weeks from the onset of the current manic episode. When duration of current episode was longer, DT had no effect. Follow-up confirmed that good responders needed a lower dose of antimanic drugs and were discharged earlier from the hospital.Conclusions: Chronobiological interventions and control of environmental stimuli can be a useful add-on for the treatment of acute mania in a hospital setting.