The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress
The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress
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DOI：
10.1016/s0006-3223(99)00237-1
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发表时间：
1999-11-01
影响因子：
10.6
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Francis, DD;Caldji, C;Meaney, MJ
自然发生的变化，在产妇护理在出生后的早期生活与发展的个体差异的行为和下丘脑-垂体-肾上腺反应的压力在大鼠。这些影响似乎是由母亲舔和梳理中枢促肾上腺皮质激素释放因子（CRF）系统的发展的影响介导的，该系统通过激活前脑去甲肾上腺素能系统来调节行为，内分泌和自主神经对应激反应的表达。这些发现为观察到的早期生活事件与成年期健康之间的关系提供了神经生物学基础。在最近的研究中，我们探讨了压力反应的个体差异的行为传递，从而对压力引起的疾病的脆弱性，跨代。(C)1999年生物精神病学学会。
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations. (C) 1999 Society of Biological Psychiatry.