Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study.
Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study.
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DOI：
10.1097/md.0000000000025091
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发表时间：
2021-03-05
期刊：
影响因子：
1.6
通讯作者：
Kuo HC
中科院分区：
文献类型：
--
作者：
Su YJ;Luo SD;Hsu CY;Kuo HC
临床上出现了几种形式的过敏，包括特应性皮炎（湿疹）、荨麻疹（荨麻疹）和过敏性鼻炎（鼻炎）等。由于其详细的发病机制仍在研究中，我们在目前的研究中旨在比较湿疹，荨麻疹和鼻炎患者之间的肠道微生物群差异。我们在这项研究中招募了19名湿疹，9名荨麻疹和11名过敏性鼻炎患者。使用16 S核糖体核糖核酸扩增子测序检查粪便样本，然后进行生物信息学和统计分析。我们比较了皮炎（湿疹），慢性荨麻疹（荨麻疹）和过敏性鼻炎（鼻炎）的微生物群。亚组之间的所有临床数据相似。微生物群结果表明，与鼻炎相比，在皮肤过敏症，荨麻疹和湿疹中发现了拟杆菌属物种。在患有特应性皮炎（湿疹）、慢性荨麻疹（荨麻疹）和过敏性鼻炎（鼻炎）的患者之间，微生物群有很大不同，因此表明存在肠-皮肤和肠-鼻轴。肠道植物群菌落在皮肤过敏和鼻过敏之间存在显著差异。拟杆菌属可能是肠道植物群和皮肤过敏之间的临床联系;其中，拟杆菌Plebeius DSM 17135与荨麻疹（荨麻疹）亚群显著相关。我们的研究结果表明，组内均匀性高，组间异质性高。湿疹，荨麻疹和鼻炎的临床症状都可以与当前研究中的特定微生物群联系起来。在这项初步研究中，瘤胃球菌科和拟杆菌目物种与过敏性疾病有关，与先前发表的几篇文章一致，厚壁菌门的丰度代表了肠道生态失调。在未来，需要更大的队列和彻底的生化研究来证实。
Several forms of allergy have been clinically presented, including, among others, atopic dermatitis (eczema), urticaria (hives), and allergic rhinitis (rhinitis). As their detailed pathogenesis continues to be researched, we aimed in the current study to compare gut microbiota differences between eczema, hives, and rhinitis patients. We enrolled 19 eczemas, nine hives, and 11 allergic rhinitis patients in this study. Fecal samples were examined using 16S ribosomal ribonucleic acid amplicon sequencing, followed by bioinformatics and statistical analyses. We compared microbiota in dermatitis (eczema), chronic urticaria (hives), and allergic rhinitis (rhinitis). All clinical data were similar between the subgroups. The microbiota results indicated that Bacteroidales species were found in skin allergies, both urticaria and eczema, when compared to rhinitis. The microbiota differs substantially between those patients with atopic dermatitis (eczema), chronic urticaria (hives), and allergic rhinitis (rhinitis), thus indicating that the gut-skin and gut-nose axes exist. Gut flora colonies differ significantly between skin allergy and nose allergy. Bacteroidales species could be a clinical link between gut flora and skin allergy; of those, Bacteroids Plebeius DSM 17135 is significantly associated with the urticaria (hives) subgroup.Conclusion. Our results demonstrated high intra-group homogeneous and high inter-group heterogeneous microbiota. The clinical symptoms of eczema, hives, and rhinitis can all be linked to specific microbiota in the current study. In this pilot study, the Ruminococcaceae and Bacteroidales species are associated with allergic disease, in line with several previous published articles, and the abundance of Firmicutes Phylum is representative of intestinal dysbiosis. In the future, a larger cohort and thorough biochemical studies are needed for confirmation.