Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI
Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI
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DOI：
10.1111/j.1477-2574.2010.00223.x
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发表时间：
2010-10-01
期刊：
影响因子：
2.9
通讯作者：
Jonas, Eduard
中科院分区：
文献类型：
--
作者：
Nilsson, Henrik;Blomqvist, Lennart;Jonas, Eduard
目的：Gd-EOB-DTPA（乙氧基苄基二亚乙基三胺五乙酸钆）是一种用于磁共振成像（MRI）的钆基肝细胞特异性造影剂。本研究的目的是确定是否肝摄取和Gd-EOB-DTPA排泄原发性胆汁性肝硬化（PBC）患者和健康controls. Methods之间的差异，以及是否可以量化的差异：Gd-EOB-DTPA增强肝脏MRI在20名健康志愿者和12例PBC患者进行。使用传统的半定量参数（C（max）、T（max）和T（1/2））以及去卷积分析后得出的无模型参数（肝提取分数[HEF]、输入相对血流量[irBF]和平均通过时间[MTT]）评估Gd-EOB-DTPA的摄取。在每个人，所有参数计算每个肝段和中位数的分段值被用来定义一个全球肝脏中位数（GLM）。结果：虽然PBC患者有相对较轻的疾病根据他们的模型为终末期肝病（MELD），Child-Pugh和马约风险评分，他们有显着降低HEF和较短的MTT值与健康对照组相比。这些差异显着增加MELD和Child-Pugh scores.Conclusions：动态肝细胞特异性对比增强MRI（DHCE-MRI）具有潜在的作用，作为一种基于成像的肝功能检查。MRI的高空间分辨率使得能够在节段和亚节段水平上评估肝功能。
Objectives: Gd-EOB-DTPA (gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid) is a gadolinium-based hepatocyte-specific contrast agent for magnetic resonance imaging (MRI). The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified.Methods: Gd-EOB-DTPA-enhanced liver MRI was performed in 20 healthy volunteers and 12 patients with PBC. The uptake of Gd-EOB-DTPA was assessed using traditional semi-quantitative parameters (C(max), T(max) and T(1/2)), as well as model-free parameters derived after deconvolutional analysis (hepatic extraction fraction [HEF], input-relative blood flow [irBF] and mean transit time [MTT]). In each individual, all parameters were calculated for each liver segment and the median of the segmental values was used to define a global liver median (GLM).Results: Although the PBC patients had relatively mild disease according to their Model for End-stage Liver Disease (MELD), Child-Pugh and Mayo risk scores, they had significantly lower HEF and shorter MTT values compared with the healthy controls. These differences significantly increased with increasing MELD and Child-Pugh scores.Conclusions: Dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) has a potential role as an imaging-based liver function test. The high spatial resolution of MRI enables hepatic function to be assessed on segmental and sub-segmental levels.