Electrocardiogram simulation with an ionic current computer model of the cardiac tissue
Electrocardiogram simulation with an ionic current computer model of the cardiac tissue
复制标题
使用心脏组织离子电流计算机模型进行心电图模拟
DOI：
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复制
发表时间：
1998
期刊：
影响因子：
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通讯作者：
L. Kappenberger
中科院分区：
文献类型：
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作者：
N. Virag;J. Vesin;L. Kappenberger
现代计算机使我们能够开发心脏模型，这可能有助于理解心律失常机制。如果基于真实的生理参数，这种模型可以显示在自然界中难以研究的现象。因此，已经实现了心脏组织的二维模型，其中每个细胞的建模基于膜离子通道。此外，已计算的基础上模拟的离子电流的ECG。该模型允许我们观察动作电位V/sub m/在心脏组织中的传播、任何心脏细胞的V/sub m/的演变以及潜在的离子电流。ECG的计算使得可以将这些量与经常使用的诊断工具相关联。已经进行了正常和病理方面的定量精确模拟，例如功能性折返。我们的模拟结果表明，实现的计算机模型的基础上的离子电流似乎准确和现实的生物模型相比。为研究心律失常的发生、预防和终止提供了新的途径。
Modern computer power allows us to develop models of the heart that may be helpful for the understanding of arrhythmia mechanisms. If based on realistic physiological parameters, such models can display phenomena difficult to study in nature. Therefore, a two-dimensional model of the cardiac tissue has been implemented, where the modeling of each cell is based on membrane ionic channels. Furthermore, an ECG has been computed based on the ionic currents simulated. This model allows us to observe the propagation of the action potentials V/sub m/ across the cardiac tissue, the evolution of V/sub m/ for any of the cardiac cells and the underlying ionic currents. The computation of the ECG makes it possible to relate these quantities with an often used diagnostic tool. Quantitatively accurate simulations of normal and pathological aspects such as functional reentries have been performed. Our simulation results show that the implemented computer model based on ionic currents seems accurate and realistic when compared to biological models. Therefore, it constitutes a new approach to study the origin, the prevention and the termination of arrhythmias.
影响因子：
20.1
作者：
LUO, CH;RUDY, Y
通讯作者：
RUDY, Y