Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease
Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease
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DOI：
10.2169/internalmedicine.47.0500
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发表时间：
2008-01-01
影响因子：
1.2
通讯作者：
Ishida, Fumihiro
中科院分区：
文献类型：
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作者：
Makishima, Hideki;Komiyama, Yuichi;Ishida, Fumihiro
乳糜泻是淋巴瘤的危险因素。在此之前，我们报告了一例弥漫性大B细胞淋巴瘤(DLBCL)合并乳糜泻的日本患者。在没有任何DLBCL复发迹象的情况下，他在恢复含面筋的饮食后突然出现胃肠道症状和皮下肿块。诊断为外周T细胞淋巴瘤(PTCL)。虽然8个月后完全缓解，但后来因PTCL导致胸腔积液和心包积液再次入院。PTCL细胞表达细胞毒分子CCR4和CXCR4，患者很快死亡。临床上，即使没有出现胃肠道症状，也应该强烈推荐该患者食用无麸质饮食。
Celiac disease is a risk factor for lymphoma. Previously, we reported a case of diffuse large B-cell lymphoma (DLBCL) associated with celiac disease in a Japanese patient. Without any signs of DLBCL recurrence, he suddenly developed gastrointestinal symptoms and subcutaneous masses after resuming a gluten-containing diet. Peripheral T-cell lymphoma (PTCL) was diagnosed. Although a complete response was seen for 8 months, he was later admitted again with pleural and pericardial effusion due to PTCL. Expression of cytotoxic molecules, CCR4 and CXCR4 were all confirmed in PTCL cells, and the patient died soon afterwards. Clinically speaking, even though no gastrointestinal symptoms were seen, a gluten-free diet should have been strongly recommended for this patient.