Preclinical Evaluation of the HDAC Inhibitor Chidamide in Transformed Follicular Lymphoma.
Preclinical Evaluation of the HDAC Inhibitor Chidamide in Transformed Follicular Lymphoma.
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HDAC 抑制剂西达本胺治疗转化性滤泡性淋巴瘤的临床前评价
DOI：
10.3389/fonc.2021.780118
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zha J
中科院分区：
文献类型：
--
作者：
Zhong M;Tan J;Pan G;Jiang Y;Zhou H;Lai Q;Chen Q;Fan L;Deng M;Xu B;Zha J
导致转化型滤泡性淋巴瘤（t-FL）的关键因素包括表观遗传修饰物的畸变作为早期和驱动事件，特别是编码组蛋白乙酰转移酶的基因突变。本研究采用CCK-8法、Annexin V/PI法和流式细胞仪分别检测了不同剂量西达米特对t-FL细胞增殖、凋亡和细胞周期的影响。Chidamide剂量依赖性地抑制t-FL细胞增殖，引起G 0/G1周期阻滞，并引发t-FL细胞凋亡。此外，在异种移植模型中体内评价西达米特对肿瘤生长的影响。RNA-seq分析显示，PI 3 K-AKT信号通路的基因表达改变可能是西达米特单药治疗t-FL的机制之一，为西达米特治疗FL的临床研究提供了依据。
The key factors leading to transformed follicular lymphoma (t-FL) include the aberrations of epigenetic modifiers as early and driving events, especially mutations in the gene encoding for histone acetyltransferase. Therefore, reversal of this phenomenon by histone deacetylase (HDAC) inhibitors is essential for the development of new treatment strategies in t-FL. Several t-FL cell lines were treated with various doses of chidamide and subjected to cell proliferation, apoptosis and cell cycle analyses with CCK-8 assay, Annexin V/PI assay and flow cytometry, respectively. Chidamide dose-dependently inhibited cell proliferation, caused G0/G1 cycle arrest and triggered apoptosis in t-FL cells. In addition, the effects of chidamide on tumor growth were evaluated in vivo in xenograft models. RNA-seq analysis revealed gene expression alterations involving the PI3K-AKT signaling pathway might account for the mechanism underlying the antitumor activity of chidamide as a single agent in t-FL. These findings provide a basis for further clinical exploration of chidamide as a promising treatment for FL.
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新型亚型选择性组蛋白脱乙酰酶抑制剂西达本胺对骨髓瘤相关骨病的治疗作用
影响因子：
10.1
作者：
He J;Chen Q;Gu H;Chen J;Zhang E;Guo X;Huang X;Yan H;He D;Yang Y;Zhao Y;Wang G;He H;Yi Q;Cai Z
通讯作者：
Cai Z
影响因子：
12.8
作者：
Maurer, Matthew J.;Bachy, Emmanuel;Ghesquieres, Herve;Ansell, Stephen M.;Nowakowski, Grzegorz S.;Thompson, Carrie A.;Inwards, David J.;Allmer, Cristine;Chassagne-Clement, Catherine;Nicolas-Virelizier, Emmanuelle;Sebban, Catherine;Lebras, Laure;Sarkozy, Clementine;Macon, William R.;Feldman, Andrew L.;Syrbu, Sergei I.;Traverse-Glehan, Alexandra;Coiffier, Bertrand;Slager, Susan L.;Weiner, George J.;Witzig, Thomas E.;Habermann, Thomas M.;Salles, Gilles;Cerhan, James R.;Link, Brian K.
通讯作者：
Link, Brian K.
影响因子：
3
作者：
Dong, Mei;Ning, Zhi-Qiang;Feng, Feng-Yi
通讯作者：
Feng, Feng-Yi
DOI：
10.1158/1078-0432.ccr-20-3741
发表时间：
2021-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Hu N;Wang F;Sun T;Xu Z;Zhang J;Bernard D;Xu S;Wang S;Kaminski M;Devata S;Phillips T;Malek SN
通讯作者：
Malek SN
影响因子：
11.5
作者：
Desmots, Fabienne;Roussel, Mikael;Fest, Thierry
通讯作者：
Fest, Thierry