Mechanism of Prostaglandin E2 Stimulation of Renin Secretion
Mechanism of Prostaglandin E2 Stimulation of Renin Secretion
复制标题
前列腺素E2刺激肾素分泌的机制
DOI：
10.3181/00379727-159-40325
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发表时间：
1978
影响因子：
--
通讯作者：
M. Bailie
中科院分区：
文献类型：
--
作者：
J. Osborn;B. Noordewier;J. Hook;M. Bailie
肾内输注乙酰胆碱、缓激肽、eledoisin和PGE2均可相似程度地增加肾血流量。钠和钾的排泄同样受到每种血管扩张剂的影响。肾素分泌在PGE2后增加，但不受乙酰胆碱、缓激肽或eledoisin的影响。提示PGE2通过直接作用于肾小球旁器官而增加肾素分泌。
Summary Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE2 increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE2 but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE2 increases renin secretion by a direct effect on the juxtaglomerular apparatus.