System-wide Analysis of the T Cell Response.
System-wide Analysis of the T Cell Response.
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DOI：
10.1016/j.celrep.2016.02.056
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发表时间：
2016-03-22
期刊：
影响因子：
8.8
通讯作者：
Quintana FJ
中科院分区：
文献类型：
--
作者：
Covacu R;Philip H;Jaronen M;Almeida J;Kenison JE;Darko S;Chao CC;Yaari G;Louzoun Y;Carmel L;Douek DC;Efroni S;Quintana FJ
T细胞受体（TCR）控制细胞对抗原的适应性免疫应答，但我们对TCR库多样性和对攻击的应答的理解仍然不完整。例如，不同个体共有的TCR克隆对生殖系基因序列的改变最小（公共克隆）在所有脊椎动物中都是可检测的，但其意义尚不清楚。虽然体积小，但斑马鱼TCR库由类似于哺乳动物中操作的过程控制。因此，我们研究了斑马鱼的TCR库和其对自身和外源抗原刺激的反应。我们发现，交叉反应性的公共TCR主导T细胞反应，赋予有限的TCR库科普不同抗原挑战的能力。脊椎动物公共TCR的这些特征可能提供了一种快速产生保护性T细胞免疫的机制，从而为更特异性的私人T细胞反应的发展提供了较短的时间窗口。
The T-cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete. For example, TCR clones shared by different individuals with minimal alteration to germline gene sequences (public clones) are detectable in all vertebrates, but their significance is unknown. Although small in size, the zebrafish TCR repertoire is controlled by processes similar to those operating in mammals. Thus, we studied the zebrafish TCR repertoire and its response to stimulation with self and foreign antigens. We found that cross-reactive public TCRs dominate the T-cell response, endowing a limited TCR repertoire with the ability to cope with diverse antigenic challenges. These features of vertebrate public TCRs might provide a mechanism for the rapid generation of protective T-cell immunity allowing a short temporal window for the development of more specific private T-cell responses.