Pink Light on Mitochondria in Autoimmunity and Parkinson Disease.

Pink Light on Mitochondria in Autoimmunity and Parkinson Disease.
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自身免疫和帕金森病线粒体上的粉红光。

DOI:
10.1016/j.cmet.2016.06.022
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发表时间:
2016
期刊:
影响因子:
29
通讯作者:
Marks,MichaelS
Marks,MichaelS
中科院分区:
生物学1区
文献类型:
--
作者:
Mantegazza,AdrianaR;Marks,MichaelS

文献摘要

被引文献

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线粒体功能障碍和T细胞自身免疫独立地参与了帕金森病的发病机制。在最近的一篇出版物Incell中,Matheoud等人。(2016)通过描述一种在帕金森病家族形式中激活的新机制将它们联系起来,在这种机制中,线粒体蛋白被处理以供CD8+T细胞识别。
Mitochondrial dysfunction and T cell autoimmunity have been independently implicated in Parkinson disease pathogenesis. In a recent publication inCell, Matheoud et al. (2016) link them by describing a new mechanism, activated in familial forms of Parkinson disease, in which mitochondrial proteins are processed for recognition by CD8+ T cells.